Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

L Jones, K Gordon-Smith, A Perry - Nature Genetics, 2021 - eprints.worc.ac.uk
Bipolar disorder (BD) is a heritable mental illness with complex etiology. We performed a
genome-wide association study (GWAS) of 41,917 BD cases and 371,549 controls of …

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

N Mullins, AJ Forstner, KS O'Connell, B Coombes… - Nature …, 2021 - nature.com
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Genome-wide association study identifies 30 loci associated with bipolar disorder

EA Stahl, G Breen, AJ Forstner, A McQuillin, S Ripke… - Nature …, 2019 - nature.com
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …

Genetic contributions to bipolar disorder: current status and future directions

KS O'Connell, BJ Coombes - Psychological Medicine, 2021 - cambridge.org
Bipolar disorder (BD) is a highly heritable mental disorder and is estimated to affect about 50
million people worldwide. Our understanding of the genetic etiology of BD has greatly …

Genetics of bipolar disorder: insights into its complex architecture and biology from common and rare variants

T Hara, Y Owada, A Takata - Journal of Human Genetics, 2023 - nature.com
Bipolar disorder (BD) is a common mental disorder characterized by recurrent mood
episodes, which causes major socioeconomic burdens globally. Though its disease …

Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder

L Hou, SE Bergen, N Akula, J Song… - Human molecular …, 2016 - academic.oup.com
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have …

De novo variation in bipolar disorder

FS Goes, M Pirooznia, M Tehan, PP Zandi… - Molecular …, 2021 - nature.com
Bipolar disorder (BD) is a common, highly heritable disorder that affects 1–2% of the world's
population. To date, most genetic studies of BD have focused on common gene variation …

The genetics of bipolar disorder

FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …

Genome-wide association study reveals two new risk loci for bipolar disorder

TW Mühleisen, M Leber, TG Schulze… - Nature …, 2014 - nature.com
Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide
association studies (GWAS) have robustly identified the first common genetic variants …

The role of genetics in bipolar disorder

C Fabbri - Bipolar disorder: from neuroscience to treatment, 2021 - Springer
Bipolar disorder (BP) is a highly heritable disease, with heritability estimated between 60
and 85% by twin studies. The underlying genetic architecture was poorly understood for …