Studies in experimental models and controlled patient trials indicate that opioids are
effective in managing neuropathic pain. However, side effects secondary to their central …

The relationship between pain severity and the extent of injury to a peripheral nerve remains
elusive. In this study, we compared the pain behavior resulting from partial (1/3–1/2 …

Peripherally acting opioids are potentially attractive drugs for the clinical management of
certain chronic pain states due to the lack of centrally mediated adverse effects. However, it …

Despite using prescribed pain medications, patients with neuropathic pain continue to
experience moderate to severe pain. There is a growing recognition of a potent peripheral …

Both peripheral nerve injury and chronic opioid treatment can result in hyperalgesia
associated with enhanced excitatory neurotransmission at the level of the spinal cord …

The present study investigated whether the loss of spinal μ-opioid receptors following
peripheral nerve injury is related to mechanical allodynia. We compared the quantity of …

Background The analgesic properties and mechanisms of loperamide hydrochloride, a
peripherally acting opioid receptor agonist, in neuropathic pain warrant further investigation …

Previous studies in rats have shown that spinal morphine loses potency and efficacy to
suppress an acute nociceptive stimulus applied to the tail or the paw following injury to …

Background Ongoing neuropathic pain is difficult to treat. We examined whether dermorphin
[D-Arg2, Lys4](1–4) amide (DALDA), a peripherally acting mu-opioid receptor agonist …

Injury to peripheral nerves often leads to abnormal pain states (hyperalgesia, allodynia and
spontaneous pain), which can remain long after the injury heals. Although opioid agonists …