[HTML][HTML] Construction of a diagnostic model for hepatitis B-related hepatocellular carcinoma using machine learning and artificial neural networks and revealing the …

S Zhang, C Jiang, L Jiang, H Chen, J Huang… - Tumour Virus …, 2023 - Elsevier
HBV infection profoundly escalates hepatocellular carcinoma (HCC) susceptibility,
responsible for a majority of HCC cases. HBV-driven immune-mediated hepatocyte …

[HTML][HTML] Bioinformatics and machine learning driven key genes screening for hepatocellular carcinoma

Y Shen, J Huang, L Jia, C Zhang, J Xu - Biochemistry and Biophysics …, 2024 - Elsevier
Liver cancer, a global menace, ranked as the sixth most prevalent and third deadliest cancer
in 2020. The challenge of early diagnosis and treatment, especially for hepatocellular …

Integrated bioinformatic analysis identifies networks and promising biomarkers for hepatitis B virus‐related hepatocellular carcinoma

Y Ji, Y Yin, W Zhang - International Journal of Genomics, 2020 - Wiley Online Library
Chronic infection with hepatitis B virus (HBV) has long been recognized as a dominant
hazard factor for hepatocellular carcinoma (HCC) and accounts for at least half of HCC …

Genomic profiling and network-level understanding uncover the potential genes and the pathways in hepatocellular carcinoma

SA El-Kafrawy, MM El-Daly, LH Bajrai… - Frontiers in …, 2022 - frontiersin.org
Data integration with phenotypes such as gene expression, pathways or function, and
protein-protein interactions data has proven to be a highly promising technique for …

Single-cell landscape identifies the immunophenotypes and microenvironments of HBV-positive and HBV-negative liver cancer

Q Zheng, Q Sun, H Yao, R Shi, C Wang… - Hepatology …, 2024 - journals.lww.com
Background: HBV infection leads to HCC and affects immunotherapy. We are exploring the
tumor ecosystem in HCC to help gain a deeper understanding and design more effective …

Screening and identification of potential biomarkers in hepatitis B virus-related hepatocellular carcinoma by bioinformatics analysis

XC Zeng, L Zhang, WJ Liao, L Ao, ZM Lin… - Frontiers in …, 2020 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most lethal cancers globally. Hepatitis B virus
(HBV) infection might cause chronic hepatitis and cirrhosis, leading to HCC. To screen …

Uncovering the immune microenvironment and molecular subtypes of hepatitis B-related liver cirrhosis and developing stable a diagnostic differential model by …

S Zhang, C Jiang, L Jiang, H Chen, J Huang… - Frontiers in Molecular …, 2023 - frontiersin.org
Background: Hepatitis B-related liver cirrhosis (HBV-LC) is a common clinical disease that
evolves from chronic hepatitis B (CHB). The development of cirrhosis can be suppressed by …

Dynamic edge-based biomarker non-invasively predicts hepatocellular carcinoma with hepatitis B virus infection for individual patients based on blood testing

Y Lu, Z Fang, M Li, Q Chen, T Zeng, L Lu… - Journal of molecular …, 2019 - academic.oup.com
Hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) is a major cause of cancer-
related deaths in Asia and Africa. Developing effective and non-invasive biomarkers of HCC …

Using quasispecies patterns of hepatitis B virus to predict hepatocellular carcinoma with deep sequencing and machine learning

S Chen, Z Zhang, Y Wang, M Fang… - The Journal of …, 2021 - academic.oup.com
Abstract Background Hepatitis B virus (HBV) infection is one of the main leading causes of
hepatocellular carcinoma (HCC) worldwide. However, it remains uncertain how the reverse …

Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progression

G Song, Y Shi, M Zhang, S Goswami, S Afridi, L Meng… - Cell discovery, 2020 - nature.com
Diverse immune cells in the tumor microenvironment form a complex ecosystem, but our
knowledge of their heterogeneity and dynamics within hepatocellular carcinoma (HCC) still …