In this study, we report the effect of endothelial progenitor cells (EPCs) on the biological
behavior of osteoclast precursors in vitro by establishing an indirect co-culture system of …

Background/Aims: Bone resorption mediated by osteoclasts plays an important role in bone
healing. Endothelial progenitor cells (EPCs) promote bone repair by stimulating …

In addition to its important transport functions, the skeletal system is involved in complex
biological activities for the regulation of blood vessels. Endothelial progenitor cells (EPCs) …

INTRODUCTION: Fracture healing and distraction osteogenesis (DO) are unique postnatal
bone formation processes, and neovascularization is critically required for successful bone …

Vascularization is a prerequisite for bone formation. Endothelial progenitor cells (EPCs)
stimulate bone formation by creating a vascular network. Moreover, EPCs secrete various …

Bone formation involves a complex crosstalk between endothelial cells (EC) and
osteodifferentiating stem cells. This functional interplay is greatly mediated by the paracrine …

Background The role of bone tissue engineering is to regenerate tissue using biomaterials
and stem cell-based approaches. Combination of two or more cell types is one of the …

Osteogenesis occurs in striking interaction with angiogenesis. There is growing evidence
that endothelial cells are involved in the modulation of osteoblast differentiation. We …

In the context of bone development and regeneration, the intimate association of the
vascular endothelium with osteogenic cells suggests that endothelial cells (ECs) may …

Recently, it has been suggested osteocytes control the activities of bone formation
(osteoblasts) and resorption (osteoclast), indicating their important regulatory role in bone …