Terminally differentiated cells can be reprogrammed to pluripotency or directly to another
differentiated cell type in vitro, a capacity termed cellular plasticity. Plasticity is not limited to …

Worldwide, the critical shortage of kidney donors has created an urgent need for tissue‐
engineered alternatives. A number of tissue engineering strategies combine three …

The prevalence of chronic kidney disease continues to outpace the development of effective
treatment strategies. For patients with advanced disease, renal replacement therapies …

The kidney is the most important organ for water homeostasis and waste excretion. It
performs several important physiological functions for homeostasis: it filters the metabolic …

Kidney organoids have enabled modeling of human development and disease. While
methods of generating the nephron lineage are well established, new protocols to induce …

The prevalence of chronic kidney disease (CKD) is rapidly increasing over the last few
decades, owing to the global increase in diabetes, and cardiovascular diseases. Dialysis …

Background: In 2012, about 16,487 people received kidney transplants in the USA whereas
95,022 candidates were on the waiting list at the end of the year. Moreover, more than 2,600 …

A kidney is an organ with relatively low basal cellular regenerative potential. However, renal
cells have a pronounced ability to proliferate after injury, which undermines that the kidney …

Recent advances in developmental biology and stem cell technology have led to the
engineering of functional organs in a dish. However, the limited size of these organoids and …

We present a bio-inspired renal microdevice that resembles the in vivo structure of a kidney
proximal tubule. For the first time, a population of tubular adult renal stem/progenitor cells …