Dialysis and allotransplantation of human kidneys represent effective therapies to replace
kidney function, but the former replaces only a small component of renal function, and the …

Chronic kidney disease (CKD) is becoming a global burden, despite recent advances in
management. CKD can begin in early life by so-called “developmental programming” or …

Recent advances in stem cell biology have enabled the generation of kidney organoids in
vitro, and further maturation of these organoids is observed after experimental …

The balance between nephron progenitor cell (NPC) renewal, survival and differentiation
ultimately determines nephron endowment and thus susceptibile to chronic kidney disease …

The mechanism and magnitude by which the mammalian kidney generates and maintains
its proximal tubules, distal tubules, and collecting ducts remain controversial. Here, we use …

Nephron progenitors in the embryonic kidney propagate while generating differentiated
nephrons. However, in mice, the progenitors terminally differentiate shortly after birth. Here …

The kidney is a model developmental paradigm of vertebrate organogenesis. As in many
other organs, kidney development involves reciprocal inductive tissue interactions between …

The human kidney develops from four progenitor populations—nephron progenitors,
ureteric epithelial progenitors, renal interstitial progenitors and endothelial progenitors …

Nonhuman primates share many developmental similarities with humans, thus they provide
an important preclinical model for understanding the ontogeny of biomarkers of kidney …

During development, distinct progenitors contribute to the nephrons versus the ureteric
epithelium of the kidney. Indeed, previous human pluripotent stem-cell-derived models of …