The role of microglia in tau accumulation is currently unclear but could provide an important
insight into the mechanisms underlying Alzheimer's disease (AD). Here, we measured the …

Alzheimer's disease (AD) and dementia in general are age-related diseases with multiple
contributing factors, including brain inflammation. Microglia, and specifically those …

In Alzheimer's disease (AD) models, AD risk variants in the microglial-expressed TREM2
gene decrease Aβ plaque–associated microgliosis and increase neuritic dystrophy as well …

In addition to tau and Aβ pathologies, inflammation plays an important role in Alzheimer's
disease (AD). Variants in APOE and TREM2 increase AD risk. ApoE4 exacerbates tau …

Microglial activation occurs early in Alzheimer's disease (AD) and previous studies reported
both detrimental and protective effects of microglia on AD progression. Here, we used CSF …

Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's
disease (AD). Both cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2), a …

The existence of individuals who remain cognitively intact despite presenting
histopathological signs of Alzheimer's disease (AD), here referred to as “Nondemented with …

Alzheimer's disease (AD) is a progressive neurodegenerative disease and is closely
associated with the accumulation of β-amyloid (Aβ) and neurofibrillary tangles (NFTs). Apart …

Non-neuronal responses in neurodegenerative disease have received increasing attention
as important contributors to disease pathogenesis and progression. Here we utilize single …

Microglia are strongly implicated in the development and progression of Alzheimer's disease
(AD), yet their impact on pathology and lifespan remains unclear. Here we utilize a CSF1R …