Genome-wide association studies (GWAS) in samples of European ancestry have identified
thousands of genetic variants associated with complex traits in humans. However, it remains …

Sex differences in physiology and disease in mammals result from the effects of three
classes of factors that are inherently unequal in males and females: reversible (activational) …

In recent years, a number of large-scale genome-wide association studies have been
published for human traits adjusted for other correlated traits with a genetic basis. In most …

Developing insight into tissue-specific transcriptional mechanisms can help improve our
understanding of how genetic variants exert their effects on complex traits and disease. In …

The potential benefits of using population isolates in genetic mapping, such as reduced
genetic, phenotypic and environmental heterogeneity, are offset by the challenges posed by …

Many neuropsychiatric disorders exhibit differences in prevalence, age of onset, symptoms
or course of illness between males and females. For the most part, the origins of these …

Many factors influence human facial morphology, including genetics, age, nutrition,
biomechanical forces, and endocrine factors. Moreover, facial features clearly differ between …

Genome-wide association studies (GWAS) for quantitative traits and disease in humans and
other species have shown that there are many loci that contribute to the observed …

Meta‐analyses of genome‐wide association studies require numerous study partners to
conduct pre‐defined analyses and thus simple but efficient analyses plans. Potential …

Most genetic variants identified in genome-wide association studies (GWASs) of complex
traits are thought to act by affecting gene regulation rather than directly altering the protein …