An open, randomised comparison of 2 or 3 days of oral ofloxacin (10 mg/kg/day) for
uncomplicated typhoid fever was conducted in 235 Vietnamese children. Multi-drug …

An open randomized comparison of 2 days (Ofx2) versus 3 days (Ofx3) of oral ofloxacin
treatment (15 mg/kg/day) was conducted with Vietnamese children between 1 and 15 years …

Background Despite concerns about safety in children, fluoroquinolone antibiotics have
become the treatment of choice in patients with multidrug-resistant typhoid fever in Vietnam …

Background. Despite concerns about safety in children, fluoroquinolone antibiotics have
become the treatment of choice in patients with multidrug-resistant typhoid fever in Vietnam …

Isolates of Salmonella enterica serovar Typhi that are multidrug resistant (MDR, resistant to
chloramphenicol, ampicillin, and trimethoprim-sulfamethoxazole) and have reduced …

We evaluated the response to therapy in a series of 876 children consecutively admitted to
The Aga Khan University Hospital with culture-proven typhoid, including 281 cases infected …

Eighteen children with bacteriologically confirmed severe typhoid fever were initially treated
intravenously with ciprofloxacin (10 mg/kg of body weight per day). Clinical cure with …

In recent years, multiresistant strains of Salmonella typhi have emerged in many tropical
countries. These strains remain highly sensitive to the fluoroquinolone antibiotics, although …

Background Drug resistant typhoid fever is a major clinical problem globally. Many of the first
line antibiotics, including the older generation fluoroquinolones, ciprofloxacin and ofloxacin …

Ofloxacin has been successfully used in the treatment of typhoid fever and Salmonella
infections of adults for many years. However, it has rarely been tried for the typhoid fever of …