A behavioral model for mapping the genetic architecture of gut-microbiota networks

L Jiang, X Liu, X He, Y Jin, Y Cao, X Zhan… - Gut …, 2021 - Taylor & Francis
The gut microbiota may play an important role in affecting human health. To explore the
genetic mechanisms underlying microbiota-host relationships, many genome-wide …

Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease

S Greenblum, PJ Turnbaugh… - Proceedings of the …, 2012 - National Acad Sciences
The human microbiome plays a key role in a wide range of host-related processes and has
a profound effect on human health. Comparative analyses of the human microbiome have …

Prospects for systems biology and modeling of the gut microbiome

FH Karlsson, I Nookaew, D Petranovic, J Nielsen - Trends in biotechnology, 2011 - cell.com
Abundant microorganisms that inhabit the human intestine are implicated in health and
disease. The gut microbiome has been studied with metagenomic tools, and over 3 million …

Genetic and transcriptional analysis of human host response to healthy gut microbiota

AL Richards, MB Burns, A Alazizi, LB Barreiro… - …, 2016 - Am Soc Microbiol
Many studies have demonstrated the importance of the gut microbiota in healthy and
disease states. However, establishing the causality of host-microbiota interactions in …

The effect of host genetics on the gut microbiome

MJ Bonder, A Kurilshikov, EF Tigchelaar, Z Mujagic… - Nature …, 2016 - nature.com
The gut microbiome is affected by multiple factors, including genetics. In this study, we
assessed the influence of host genetics on microbial species, pathways and gene ontology …

A system biology perspective on environment–host–microbe interactions

L Chen, S Garmaeva, A Zhernakova, J Fu… - Human Molecular …, 2018 - academic.oup.com
A vast, complex and dynamic consortium of microorganisms known as the gut microbiome
colonizes the human gut. Over the past few decades, we have developed an increased …

Host genes and their effect on the intestinal microbiome garden

J Jacobs, J Braun - Genome medicine, 2014 - Springer
We are only beginning to understand the relationship between host genetics and the gut
microbiome. Two recent studies help to disentangle this interaction and show that genetic …

Modeling spatial interaction networks of the gut microbiota

X Cao, A Dong, G Kang, X Wang, L Duan, H Hou… - Gut …, 2022 - Taylor & Francis
How the gut microbiota is organized across space is postulated to influence microbial
succession and its mutualistic relationships with the host. The lack of dynamic or perturbed …

Using the natural variation of mouse populations to understand host-gut microbiome interactions

E Org, AJ Lusis - Drug Discovery Today: Disease Models, 2018 - Elsevier
One approach to understanding gut microbiome–host interactions, described in this review,
is to examine how natural variation in a model organism, where environmental factors can …

Genetic and environmental control of host-gut microbiota interactions

E Org, BW Parks, JWJ Joo, B Emert… - Genome …, 2015 - genome.cshlp.org
Genetics provides a potentially powerful approach to dissect host-gut microbiota
interactions. Toward this end, we profiled gut microbiota using 16s rRNA gene sequencing …