Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts …

P Fagone, R Ciurleo, SD Lombardo, C Iacobello… - Autoimmunity …, 2020 - Elsevier
The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
disease (COVID-19) has posed a serious threat to global health. As no specific therapeutics …

Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients

J Diray-Arce, S Fourati, ND Jayavelu, R Patel… - Cell Reports …, 2023 - cell.com
The IMPACC cohort, composed of> 1,000 hospitalized COVID-19 participants, contains five
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1 …

SARS-CoV-2 escaped natural immunity, raising questions about vaccines and therapies

E Andreano, R Rappuoli - Nature medicine, 2021 - nature.com
SARS-CoV-2 escaped natural immunity, raising questions about vaccines and therapies |
Nature Medicine Skip to main content Thank you for visiting nature.com. You are using a …

[HTML][HTML] Duration of post–COVID-19 symptoms is associated with sustained SARS-CoV-2–specific immune responses

JK Files, S Sarkar, TR Fram, S Boppana, S Sterrett… - JCI insight, 2021 - ncbi.nlm.nih.gov
A subset of COVID-19 patients exhibit post-acute sequelae of COVID-19 (PASC), but little is
known about the immune signatures associated with these syndromes. We investigated …

Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?

SY Zhang, Q Zhang, JL Casanova, HC Su… - Nature Reviews …, 2020 - nature.com
Severe COVID-19 is rare in previously healthy individuals who are less than 50 years of
age, affecting probably no more than 1 in 1,000 such infected individuals. We suggest that …

Lessons learned: new insights on the role of cytokines in COVID-19

M Buszko, A Nita-Lazar, JH Park, PL Schwartzberg… - Nature …, 2021 - nature.com
In the midst of resurging COVID-19 cases, the second NIH/FDA virtual COVID-19 and
Cytokines symposium was held on 1 December 2020, focusing on longitudinal studies of …

Unraveling the mystery surrounding post-acute sequelae of COVID-19

RK Ramakrishnan, T Kashour, Q Hamid… - Frontiers in …, 2021 - frontiersin.org
More than one year since its emergence, corona virus disease 2019 (COVID-19) is still
looming large with a paucity of treatment options. To add to this burden, a sizeable subset of …

Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets

DK Singh, B Singh, SR Ganatra, M Gazi, J Cole… - Nature …, 2021 - nature.com
Non-human primate models will expedite therapeutics and vaccines for coronavirus disease
2019 (COVID-19) to clinical trials. Here, we compare acute severe acute respiratory …

Daily viral kinetics and innate and adaptive immune response assessment in COVID-19: a case series

P Vetter, CS Eberhardt, B Meyer, PA Martinez Murillo… - MSphere, 2020 - Am Soc Microbiol
Viral shedding patterns and their correlations with immune responses are still poorly
characterized in mild coronavirus (CoV) disease 2019 (COVID-19). We monitored shedding …

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

ER Mann, M Menon, SB Knight, JE Konkel… - Science …, 2020 - science.org
COVID-19 pathogenesis is associated with an exaggerated immune response. However, the
specific cellular mediators and inflammatory components driving diverse clinical disease …