Circulating immune profile can predict survival of metastatic uveal melanoma patients: results of an exploratory study

E Rossi, IG Zizzari, A Di Filippo… - Human Vaccines & …, 2022 - Taylor & Francis
Metastatic uveal melanoma (UM) is a poor prognosis malignancy. Immunotherapy is
commonly employed, despite the low activity, considering the lack of other effective systemic …

Immunological backbone of uveal melanoma: is there a rationale for immunotherapy?

E Rossi, G Schinzari, IG Zizzari, BA Maiorano… - Cancers, 2019 - mdpi.com
No standard treatment has been established for metastatic uveal melanoma (mUM).
Immunotherapy is commonly used for this disease even though UM has not been included …

Evaluation of the modified immune prognostic index to prognosticate outcomes in metastatic uveal melanoma patients treated with immune checkpoint inhibitors

MS Sander, I Stukalin, IA Vallerand, S Goutam… - Cancer …, 2021 - Wiley Online Library
Background Metastatic uveal melanoma (MUM) is associated with poor survival and inferior
response to immune checkpoint inhibitor (ICI) therapy when compared with metastatic …

Immunotherapy in uveal melanoma: novel strategies and opportunities for personalized treatment

C Masaoutis, S Kokkali… - Expert opinion on …, 2021 - Taylor & Francis
Introduction Uveal melanoma (UM) is the most common intraocular cancer and represents a
discrete subtype of melanoma. Metastatic disease, which occurs in half of patients, has a …

[HTML][HTML] Immune profiling of uveal melanoma identifies a potential signature associated with response to immunotherapy

Y Qin, K Bollin, MP De MacEdo… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background To date, no systemic therapy, including immunotherapy, exists to improve
clinical outcomes in metastatic uveal melanoma (UM) patients. To understand the role of …

Parallel profiling of immune infiltrate subsets in uveal melanoma versus cutaneous melanoma unveils similarities and differences: a pilot study

Y Qin, M Petaccia de Macedo, A Reuben… - …, 2017 - Taylor & Francis
The low response rates to immunotherapy in uveal melanoma (UM) sharply contrast with
reputable response rates in cutaneous melanoma (CM) patients. To characterize the …

Optimizing immune checkpoint blockade in metastatic uveal melanoma: exploring the association of overall survival and the occurrence of adverse events

EAT Koch, A Petzold, E Dippel, M Erdmann… - Frontiers in …, 2024 - frontiersin.org
Introduction Despite recent advancements in the treatment of metastatic uveal melanoma
(UM), the availability of further treatment options remains limited and the prognosis …

Clinical determinants of long-term survival in metastatic uveal melanoma

EAT Koch, A Petzold, A Wessely, E Dippel… - Cancer Immunology …, 2022 - Springer
This study aimed to identify prognostic factors in patients with metastatic uveal melanoma
(UM) that were associated with long-term survival in a real-world setting. A total of 94 …

Prognostic hematologic biomarkers following immune checkpoint inhibition in metastatic uveal melanoma

JJ Waninger, LA Fecher, C Lao, S Yentz, MD Green… - Cancers, 2022 - mdpi.com
Simple Summary Uveal melanoma is a rare form of melanoma but is the most common
tumor in the eye. Despite having effective treatments for the initial tumor, many patients …

The immune cell landscape of metastatic uveal melanoma correlates with overall survival

A Tosi, R Cappellesso, AP Dei Tos, V Rossi… - Journal of Experimental …, 2021 - Springer
Background Uveal melanoma (UM) represents the most common primary intra-ocular
malignancy in adults. Up to 50% of the patients develop distant metastases within 10 years …