Glucocorticoids (GCs) exert via glucocorticoid receptors (GRs) potent anti‐inflammatory and
immunosuppressive effects. Emerging evidence indicates that an inflammatory process is …

Inflammation and oxidative stress have been closely associated with the pathogenesis of
neurodegenerative disorders, including Parkinson's disease (PD). The expression of …

Among the pathogenic processes contributing to dopaminergic neuron (DN) death in
Parkinson disease (PD), evidence points to non–cell-autonomous mechanisms, particularly …

The precise contribution of astrocytes in neuroinflammatory process occurring in Parkinson's
disease (PD) is not well characterized. In this study, using GRCx30CreERT2 mice that are …

Chronic inflammation is a major characteristic feature of Parkinson's disease (PD). Studies
in PD patients show evidence of augmented levels of potent pro-inflammatory molecules eg …

Increasing evidence suggest that excessive inflammatory responses from overactivated
microglia play a critical role in Parkinson's disease (PD), contributing to, or exacerbating …

The present study compared 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-
induced microglial activation in 3 different groups, sham-operated (SHM) mice …

Alterations in developmental programming of neuroendocrine and immune system function
may critically modulate vulnerability to various diseases. In particular, genetic factors …

Glucocorticoids, recognized as stress-related steroid hormones secreted from adrenal
glands, have multiple roles in brain function. The concentration of glucocorticoids is …

Isolation of glucocorticoids (GCs) from adrenal glands followed by synthesis led rapidly to
their first clinical application, about 70 years ago, for treatment of rheumatoid arthritis. To this …