Malaria remains one of the most serious global infectious diseases. An important target for
antimalarial chemotherapy is the enzyme dihydroorotate dehydrogenase from Plasmodium …

Malaria is one of the leading causes of severe infectious disease worldwide; yet, our ability
to maintain effective therapy to combat the illness is continually challenged by the …

Malaria persists as one of the most devastating global infectious diseases. The pyrimidine
biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) has been identified as a new …

Based on medicinal chemistry tools, new compounds for malaria treatment were designed.
The scaffolds of the drugs used to treat malaria, such as chloroquine, primaquine …

A Plasmodium falciparum dihydroorotate dehydrogenase (Pf DHODH) inhibitor that is potent
(KI= 15 nM) and species-selective (> 5000-fold over the human enzyme) was identified by …

According to the World Health Organization, half of the World's population, approximately
3.3 billion people, is at risk for developing malaria. Nearly 700,000 deaths each year are …

In this work, we designed and synthesized 35 new triazolopyrimidine, pyrazolopyrimidine
and quinoline derivatives as P. falciparum inhibitors (3D7 strain). Thirty compounds …

Malaria puts at risk nearly half the world's population and causes high mortality in sub-
Saharan Africa, while drug resistance threatens current therapies. The pyrimidine …

Inhibition of dihydroorotate dehydrogenase (DHODH) for P. falciparum potentially
represents a new treatment option for malaria, since DHODH catalyzes the rate-limiting step …

Plasmodium falciparum, the causative agent of the most deadly form of human malaria, is
unable to salvage pyrimidines and must rely on de novo biosynthesis for survival …