The state of long non-coding RNA biology

JS Mattick - Non-coding RNA, 2018 - mdpi.com
Transcriptomic studies have demonstrated that the vast majority of the genomes of mammals
and other complex organisms is expressed in highly dynamic and cell-specific patterns to …

Long noncoding RNAs in cell biology

MB Clark, JS Mattick - Seminars in cell & developmental biology, 2011 - Elsevier
Whole genome transcriptomic analyses have identified large numbers of dynamically
expressed long non-protein-coding RNAs (lncRNAs) in mammals and other animals whose …

Long noncoding RNAs in mammalian development and diseases

P Saha, S Verma, RU Pathak, RK Mishra - Long Non Coding RNA Biology, 2017 - Springer
Following analysis of sequenced genomes and transcriptome of many eukaryotes, it is
evident that virtually all protein-coding genes have already been discovered. These …

The functions of long noncoding RNAs in development and stem cells

RBT Perry, I Ulitsky - Development, 2016 - journals.biologists.com
Eukaryotic genomes are pervasively transcribed, with tens of thousands of RNAs emanating
from uni-and bi-directional promoters and from active enhancers. In vertebrates, thousands …

Long noncoding RNAs in organogenesis: making the difference

P Grote, BG Herrmann - Trends in Genetics, 2015 - cell.com
A large proportion of the cellular transcriptome of higher vertebrates consists of non-protein
coding transcripts, among them the long noncoding RNAs (lncRNAs). Although lncRNAs are …

Unique features of long non-coding RNA biogenesis and function

JJ Quinn, HY Chang - Nature reviews genetics, 2016 - nature.com
Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous
biological processes across every branch of life. Although initially discovered as mRNA-like …

Towards higher-resolution and in vivo understanding of lncRNA biogenesis and function

LL Chen - Nature Methods, 2022 - nature.com
Recent studies have revealed multifaceted roles of long noncoding RNAs (lncRNAs) in gene
regulation, accompanying an increased understanding of lncRNA processing, localization …

Long noncoding RNAs: past, present, and future

JTY Kung, D Colognori, JT Lee - Genetics, 2013 - academic.oup.com
Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a
potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been …

The specificity of long noncoding RNA expression

BS Gloss, ME Dinger - Biochimica et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
Over the last decade, long noncoding RNAs (lncRNAs) have emerged as a fundamental
molecular class whose members play pivotal roles in the regulation of the genome. The …

Molecular mechanisms of long noncoding RNAs

KC Wang, HY Chang - Molecular cell, 2011 - cell.com
Long noncoding RNAs (lncRNAs) are an important class of pervasive genes involved in a
variety of biological functions. Here we discuss the emerging archetypes of molecular …