Collective endpoint of visual acuity and contrast sensitivity function from hierarchical Bayesian joint modeling

Y Zhao, LA Lesmes, M Dorr, ZL Lu - Journal of Vision, 2023 - jov.arvojournals.org
Clinical trials typically analyze multiple endpoints for signals of efficacy. To improve signal
detection for treatment effects using the high-dimensional data collected in trials, we …

Non-parametric hierarchical Bayesian modeling enables statistical inference on contrast sensitivity at individual spatial frequencies

Y Zhao, LA Lesmes, M Dorr… - … Ophthalmology & Visual …, 2023 - iovs.arvojournals.org
Purpose: For consideration as a safety and efficacy endpoint in clinical trials, contrast
sensitivity (CS) must be measured at multiple spatial frequencies. We developed two non …

Non-parametric hierarchical Bayesian modeling of the contrast sensitivity function

Y Zhao, LA Lesmes, M Dorr, ZL Lu - Journal of Vision, 2023 - jov.arvojournals.org
The qCSF has been used to assess spatial vision in normal and clinical populations.
Because it uses the log parabola CSF model, the estimated contrast sensitivities (CSs) …

Hierarchical Bayesian modeling of contrast sensitivity functions in a within-subject design

Y Zhao, LA Lesmes, F Hou, ZL Lu - Journal of Vision, 2021 - jov.arvojournals.org
Recent development of the quick contrast sensitivity function (qCSF) method has made it
possible to obtain accurate, precise, and efficient contrast sensitivity function (CSF) …

Mapping the contrast sensitivity of the visual field with bayesian adaptive qVFM

P Xu, LA Lesmes, D Yu, ZL Lu - Frontiers in Neuroscience, 2020 - frontiersin.org
Current clinical evaluation, which focuses on central vision, could be improved through
characterization of residual vision with peripheral testing of visual acuity, contrast sensitivity …

[HTML][HTML] Quantifying uncertainty of the estimated visual acuity behavioral function with hierarchical Bayesian modeling

Y Zhao, LA Lesmes, M Dorr… - … Vision Science & …, 2021 - iovs.arvojournals.org
Purpose: The goal of this study is to develop a hierarchical Bayesian model (HBM) to better
quantify uncertainty in visual acuity (VA) tests by incorporating the relationship between VA …

[HTML][HTML] Bayesian adaptive estimation of the contrast sensitivity function: the quick CSF method

LA Lesmes, ZL Lu, J Baek, TD Albright - Journal of vision, 2010 - tvst.arvojournals.org
The contrast sensitivity function (CSF) predicts functional vision better than acuity, but long
testing times prevent its psychophysical assessment in clinical and practical applications …

[HTML][HTML] Evaluating the performance of the quick CSF method in detecting contrast sensitivity function changes

F Hou, LA Lesmes, W Kim, H Gu, MA Pitt… - Journal of …, 2016 - tvst.arvojournals.org
The contrast sensitivity function (CSF) has shown promise as a functional vision endpoint for
monitoring the changes in functional vision that accompany eye disease or its treatment …

The reliability of the quick CSF method for contrast sensitivity assessment in low vision

L Lesmes, J Wallis, ML Jackson… - … Ophthalmology & Visual …, 2013 - iovs.arvojournals.org
Purpose: The contrast sensitivity function (CSF) presents a better characteristic of functional
vision than visual acuity. The quick CSF is a novel adaptive method that greatly reduces …

Bayesian inference of two-dimensional contrast sensitivity function from data obtained with classical one-dimensional algorithms is efficient

X Wang, H Wang, J Huang, Y Zhou… - Frontiers in …, 2017 - frontiersin.org
The contrast sensitivity function that spans the two dimensions of contrast and spatial
frequency is crucial in predicting functional vision both in research and clinical applications …