Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning

SM Rodrigues, GE Schafe, JE LeDoux - Journal of neuroscience, 2001 - Soc Neuroscience
The lateral nucleus of the amygdala (LA) is an essential component of the neural circuitry
underlying Pavlovian fear conditioning. Although blockade of NMDA receptors in LA and …

NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala

KA Goosens, S Maren - European Journal of Neuroscience, 2004 - Wiley Online Library
We examined the contribution of N‐methyl‐d‐aspartate (NMDA) receptors (NMDARs) to the
acquisition and expression of amygdaloid plasticity and Pavlovian fear conditioning using …

Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala

F Sotres-Bayon, DEA Bush, JE LeDoux - Neuropsychopharmacology, 2007 - nature.com
N-methyl-D-aspartate receptors (NMDARs) contribute to synaptic plasticity underlying
learning in a variety of brain systems. Fear extinction, which involves learning to suppress …

Distinct populations of NMDA receptors at subcortical and cortical inputs to principal cells of the lateral amygdala

MG Weisskopf, JE LeDoux - Journal of neurophysiology, 1999 - journals.physiology.org
Distinct populations of NMDA receptors at subcortical and cortical inputs to principal cells of
the lateral amygdala. Fear conditioning involves the transmission of sensory stimuli to the …

Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats

H Lee, JJ Kim - Journal of Neuroscience, 1998 - Soc Neuroscience
NMDA receptors in the amygdala seem to be critical for fear conditioning in naive rats.
Recent spatial-learning studies suggest that previous learning protected animals from the …

Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear …

DL Walker, M Davis - Learning & Memory, 2008 - learnmem.cshlp.org
Within the amygdala, most N-methyl-D-aspartic acid (NMDA) receptors consist of NR1
subunits in combination with either NR2A or NR2B subunits. Because the particular subunit …

NMDA receptor antagonism in the basolateral but not central amygdala blocks the extinction of Pavlovian fear conditioning in rats

JM Zimmerman, S Maren - European Journal of Neuroscience, 2010 - Wiley Online Library
Glutamate receptors in the basolateral complex of the amygdala (BLA) are essential for the
acquisition, expression and extinction of Pavlovian fear conditioning in rats. Recent work …

NMDA receptor antagonism in the lateral/basolateral but not central nucleus of the amygdala prevents the induction of facilitated learning in response to stress

TJ Shors, PR Mathew - Learning & Memory, 1998 - learnmem.cshlp.org
Exposure to an acute stressful event facilitates classical eye-blink conditioning in the male
rat. The facilitation persists for days after the stressor and its induction is prevented by …

Injections of the NMDA receptor antagonist aminophosphonopentanoic acid into the lateral nucleus of the amygdala block the expression of fear-potentiated startle …

M Fendt - Journal of Neuroscience, 2001 - Soc Neuroscience
NMDA receptors within the amygdala play an important role in the acquisition and
expression of conditioned fear. Because amygdaloid injections of NMDA receptor …

[HTML][HTML] Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion

C Barkus, SB McHugh, R Sprengel, PH Seeburg… - European journal of …, 2010 - Elsevier
David De Wied had a fundamental interest in the brain and behaviour, with a particular
interest in the interface between cognition and emotion, and how impairments at this …