The molecular causes and the genetic and environmental modifying factors of the sporadic
form of Alzheimer's disease (AD) remain elusive. Extrapolating from the known mutations …

Loss of synapses and dying back of axons are considered early events in brain
degeneration during Alzheimer's disease. This is accompanied by an aberrant behavior of …

The subcellular localization of organelles, mRNAs and proteins is particularly challenging in
neurons. Owing to their extended morphology, with axons in humans exceeding a meter in …

Mutations in amyloid precursor protein (APP), tau and apolipoprotein E4 (ApoE4) lead to
Alzheimer's disease (AD) or related pathologies. Pathogenesis and interactions between …

Tau, as a microtubule (MT)-associated protein, participates in key neuronal functions such
as the regulation of MT dynamics, axonal transport, and neurite outgrowth. Alternative …

Since the initial description one hundred years ago by Dr. Alois Alzheimer, the disorder that
bears his name has been characterized by the occurrence of two brain lesions: amyloid …

One of the defining pathological features of Alzheimer disease (AD) is the intraneuronal
accumulation of tau. The tau that forms these accumulations is altered both …

Tau is a microtubule-associated protein that is involved in both normal and pathological
processes in neurons. Since the discovery and characterization of tau over 40 years ago …

Alzheimer's disease (AD) is a common neurodegenerative disorder that causes senile
dementia. The pathological characteristics are the appearance of neurofibrillary tangles …

Phosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary
tangles in Alzheimer's disease. To investigate the effects of specific phosphorylated tau …