Molecular genetic analysis is revealing the etiologies of Alzheimer's disease (AD) and
related dementias. Here we review genetic and molecular biological evidence suggesting …

Elevated tau expression has been proposed as a possible basis for impaired axonal
transport in Alzheimer's disease. To address this hypothesis, we analyzed the movement of …

The role of brain somatic mutations in Alzheimer's disease (AD) is not well understood.
Here, we perform deep whole-exome sequencing (average read depth 584×) in 111 …

The neuropathology associated with Alzheimer's disease (AD) is characterized by the
presence of extracellularly neuritic plaques, intracellularly neurofibrillary tangles and the …

Some neurodegenerative diseases including Alzheimer's disease (AD) and amyotrophic
lateral sclerosis (ALS) exhibit prominent defects in axonal transport. These defects can …

Hyperphosphorylated tau has long been proposed as the key molecule disrupting normal
neuronal microtubule dynamics and leading to neurofibrillary degeneration in Alzheimer …

Both Alzheimer's disease (AD) and almost every second case of frontotemporal lobar
degeneration (FTLD) are characterized by the deposition of hyperphosphorylated forms of …

Neurodegenerative disorders constitute a growing concern worldwide. Their incidence has
increased steadily, in particular among the elderly, a high-risk population that is becoming …

Research into the molecular mechanisms of Alzheimer disease (AD) continues to clarify
important issues in aberrant protein processing while seeking to identify therapeutic targets …

Axonal transport, the process by which membrane-bound organelles and soluble protein
complexes are transported into and out of axons, ensures proper function of the neuron …