Background With the exception of APOE ε4 allele, the common genetic risk factors for
sporadic Alzheimer's Disease (AD) are unknown. Methods and Findings We completed a …

Alzheimer's disease (AD) is a complex disorder influenced by environmental and genetic
factors. Recent work has identified 11 AD markers in 10 loci. We used Genome-wide …

More than 20 genetic loci have been associated with risk for Alzheimer's disease (AD), but
reported genome-wide significant loci do not account for all the estimated heritability and …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with considerable
evidence suggesting an initiation of disease in the entorhinal cortex and hippocampus and …

Genome-wide association studies have identified many loci associated with Alzheimer's
dementia. However, these variants only explain part of the heritability of Alzheimer's disease …

Introduction Genetic associations for endophenotypes of Alzheimer's disease (AD) in
cognitive stages preceding AD have not been thoroughly evaluated. Methods We conducted …

Background Recent genome-wide association studies have identified genetic loci that jointly
make a considerable contribution to risk of developing Alzheimer's disease (AD). Because …

Late-onset Alzheimer's disease (AD) is 50–70% heritable with complex genetic
underpinnings. In addition to Apoliprotein E (APOE) ε4, the major genetic risk factor, recent …

Objective: To investigate the top late-onset Alzheimer disease (LOAD) risk loci detected or
confirmed by the International Genomics of Alzheimer's Project for association with brain …

Objective To investigate whether genome-wide association study (GWAS)–validated and
GWAS-promising candidate loci influence magnetic resonance imaging measures and …