Accessible chromatin is important for RNA polymerase II recruitment and transcription
initiation at eukaryotic promoters. We investigated the mechanistic links between promoter …

The ATP-dependent chromatin remodeling complex SWI/SNF regulates transcription and
has been implicated in promoter nucleosome eviction. Efficient nucleosome disassembly by …

Chromatin-remodeling enzymes can overcome strong histone-DNA interactions within the
nucleosome to regulate access of DNA-binding factors to the genetic code. By unzipping …

We show that nucleosomes exert a maximal amount of hindrance to the one-dimensional
diffusion of transcription factors (TFs) when they are present between TFs and their cognate …

Nucleosomes present a barrier for the binding of most transcription factors (TFs). However,
special TFs known as nucleosome-displacing factors (NDFs) can access embedded sites …

The genomic positions of nucleosomes are a defining feature of the cell's epigenomic state,
but signal-dependent transcription factors (SDTFs), upon activation, bind to specific genomic …

The positioning of nucleosomes within the coding regions of eukaryotic genes is aligned
with respect to transcriptional start sites. This organization is likely to influence many genetic …

Nucleosome repositioning at gene promoters is a fundamental aspect of the regulation of
gene expression. However, the extent to which nucleosome repositioning is used within …

The histone N-terminal tails have been shown previously to be important for chromatin
assembly, remodeling, and stability. We have tested the ability of human SWI-SNF (hSWI …

To understand the mechanisms by which the chromatin-remodeling SWI/SNF complex
interacts with DNA and alters nucleosome organization, we have imaged the SWI/SNF …