Highlights•Nucleosomes exhibit diverse types of motion, such as sliding, DNA unwrapping,
and disassembly.•The energy landscape of nucleosomes contains multitude of metastable …

In the eukaryotic nucleus, the structural context for proalthough this property has yet to be
demonstrated for teins involved in transcriptional regulation, DNA replica-CHRAC. In …

Most promoters in yeast contain a nucleosome-depleted region (NDR), but the mechanisms
by which NDRs are established and maintained in vivo are currently unclear. We have …

The nucleosome is a small unit of chromatin, which is dynamic in eukaryotes. Chromatin
conformation and post-translational modifications affect nucleosome dynamics under certain …

Gene regulation in eukaryotes requires the controlled access of sequence-specific
transcription factors (TFs) to their sites in a chromatin landscape dominated by …

Chromatin remodeling enzymes use the energy of ATP hydrolysis to alter histone–DNA
contacts and regulate DNA-based processes in eukaryotes. Whether different subfamilies of …

Nucleosome positioning is a key factor in the regulation of transcription, as nucleosomes
regulate the dynamic accessibility of chromatin for transcription factor binding and interact …

Nucleosome positioning is crucial for the genome's function. Though the role of DNA
sequence in positioning nucleosomes is well understood, a detailed mechanistic …

The Drosophila nucleosome remodeling factor (NURF) is a protein complex of four subunits
that assists transcription factor-mediated perturbation of nucleosomes in an ATP-dependent …

Chromatin-remodeling complexes regulate access to nucleosomal DNA by mobilizing
nucleosomes in an ATP-dependent manner. In this study, we find that chromatin remodeling …