Nucleosome positioning and kinetics near transcription-start-site barriers are controlled by interplay between active remodeling and DNA sequence
We investigate how DNA sequence, ATP-dependent chromatin remodeling and nucleosome-
depleted 'barriers' co-operate to determine the kinetics of nucleosome organization, in a …
depleted 'barriers' co-operate to determine the kinetics of nucleosome organization, in a …
Octamer transfer and creation of stably remodeled nucleosomes by human SWI-SNF and its isolated ATPases
ML Phelan, GR Schnitzler… - Molecular and cellular …, 2000 - Taylor & Francis
Chromatin remodeling complexes help regulate the structure of chromatin to facilitate
transcription. The multisubunit human (h) SWI-SNF complex has been shown to remodel …
transcription. The multisubunit human (h) SWI-SNF complex has been shown to remodel …
Human SWI/SNF interconverts a nucleosome between its base state and a stable remodeled state
G Schnitzler, S Sif, RE Kingston - Cell, 1998 - cell.com
The human SWI/SNF complex remodels nucleosome structure in an ATP-dependent
manner, although the nature of this change has not been determined. Here we show that …
manner, although the nature of this change has not been determined. Here we show that …
Kinetics and thermodynamics of phenotype: unwinding and rewinding the nucleosome
Chromatin “remodeling” is widely accepted as the mechanism that permits access to DNA by
the transcription machinery. To date, however, there has been no experimental …
the transcription machinery. To date, however, there has been no experimental …
Long-range effects of histone point mutations on DNA remodeling revealed from computational analyses of SIN-mutant nucleosome structures
F Xu, AV Colasanti, Y Li, WK Olson - Nucleic acids research, 2010 - academic.oup.com
The packaging of DNA into nucleosomes impedes the binding and access of molecules
involved in its processing. The SWI/SNF multi-protein assembly, found in yeast, is one of …
involved in its processing. The SWI/SNF multi-protein assembly, found in yeast, is one of …
Direct imaging of human SWI/SNF-remodeled mono-and polynucleosomes by atomic force microscopy employing carbon nanotube tips
Chromatin-remodeling complexes alter chromatin structure to facilitate, or in some cases
repress, gene expression. Recent studies have suggested two potential pathways by which …
repress, gene expression. Recent studies have suggested two potential pathways by which …
The effect of an intervening promoter nucleosome on gene expression
Nucleosomes, which are the basic packaging units of chromatin, are stably positioned in
promoters upstream of most stress-inducible genes. These promoter nucleosomes are …
promoters upstream of most stress-inducible genes. These promoter nucleosomes are …
Transcriptional activation domains interact with ATPase subunits of yeast chromatin remodelling complexes SWI/SNF, RSC and INO80
EC Wendegatz, M Engelhardt, HJ Schüller - 2024 - researchsquare.com
Chromatin remodelling complexes (CRC) are ATP-dependent molecular machines
important for the dynamic organization of nucleosomes along eukaryotic DNA. CRCs …
important for the dynamic organization of nucleosomes along eukaryotic DNA. CRCs …
Atomic force microscopy imaging of SWI/SNF action: mapping the nucleosome remodeling and sliding
We propose a combined experimental (atomic force microscopy) and theoretical study of the
structural and dynamical properties of nucleosomes. In contrast to biochemical approaches …
structural and dynamical properties of nucleosomes. In contrast to biochemical approaches …
In vivo role for the chromatin-remodeling enzyme SWI/SNF in the removal of promoter nucleosomes by disassembly rather than sliding
CR Brown, C Mao, E Falkovskaia, JK Law… - Journal of Biological …, 2011 - ASBMB
Analysis of in vivo chromatin remodeling at the PHO5 promoter of yeast led to the conclusion
that remodeling removes nucleosomes from the promoter by disassembly rather than sliding …
that remodeling removes nucleosomes from the promoter by disassembly rather than sliding …