Nucleosome not only directly affects cellular processes, such as DNA replication,
recombination, and transcription, but also severs as a fundamentally important target of …

Nucleosome is the fundamental unit of eukaryotic chromatin, in which DNA wraps around
histone proteins. It is essential to know the regulation of DNA unwrapping because the DNA …

ATP-dependent chromatin remodeling complexes can induce the translocation (sliding) of
nucleosomes in cis along DNA, but the mechanism by which sliding occurs is not well …

For activation or repression of genes in eukaryotic organisms, the chromatin structure has to
be adapted. This action is performed at least in part by dedicated motor proteins, the …

Transcription factors (TF) require access to target sites within nucleosomes to initiate
transcription. The target site position within the nucleosome significantly influences TF …

We utilized a site-specific cross-linking technique to investigate the mechanism of
nucleosome remodeling by hSWI/SNF. We found that a single cross-link between H2B and …

Impediments to DNA access due to assembly of the eukaryotic genome into chromatin are in
part overcome by the activity of ATP‐dependent chromatin‐remodeling complexes. These …

Nucleosome positioning is a key factor for transcriptional regulation. Nucleosomes regulate
the dynamic accessibility of chromatin and interact with the transcription machinery at every …

The SWI/SNF complex participates in the restructuring of chromatin for transcription. The
function of the yeast SWI/SNF complex in the remodeling of a nucleosome array has now …

ATP‐dependent chromatin remodeling complexes play a critical role in chromatin dynamics.
A large number of in vitro studies have pointed towards nucleosome sliding as the principal …