Within the genomes of metazoans, nucleosomes are highly organised adjacent to the
binding sites for a subset of transcription factors. Here we have sought to investigate which …

Nu cleosome R emodeling F actor (NURF) is an ATP-dependent nucleosome remodeling
complex that alters chromatin structure by catalyzing nucleosome sliding, thereby exposing …

Chromatin is a formidable barrier to transcription. Nucleosome density is lowest over the
regulatory regions of active genes, and many repressed genes have a tightly positioned …

The~'ole of the nucleosome in the folding of DNA has often been thought of as purely a
packaging one. However, the precise folding of regulatory sequences of genes around the …

Nucleosomes represent the basic building block of chromatin and provide an important
mechanism by which cellular processes are controlled. The locations of nucleosomes …

The multisubunit SWI/SNF and RSC complexes utilize energy derived from ATP hydrolysis
to mobilize nucleosomes and render the DNA accessible for various nuclear processes …

Gene regulation involves the generation of a local chromatin topology that is conducive to
transcription. Several classes of chromatin remodelling activity have been shown to play a …

Background The binding of transcription factors (TFs) to specific DNA sequences is an initial
and crucial step of transcription. In eukaryotes, this process is highly dependent on the local …

Organisms rely on the establishment of specific gene expression patterns to ensure proper
development and response to external cues. Transcription factors (TFs) and cofactors are …

A central problem in the control of eukaryotic gene expression is how the compaction of
DNA in chromatin is overcome to allow the initiation and elongation of transcription (1–6) …