Nucleosome positioning is proposed to have an essential role in facilitating the regulated
transcription of eukaryotic genes. Some transcription factors can bind to DNA when it is …

Nucleosome organization has a key role in transcriptional regulation, yet the precise
mechanisms establishing nucleosome locations and their effect on transcription are unclear …

Abstract The Swi/Snf family of nucleosome-remodeling complexes has been shown to play
important roles in gene expression throughout eukaryotes. Genetic and biochemical studies …

Transcription factor (TF) binding to its DNA target site plays an essential role in gene
regulation. The location, orientation and spacing of transcription factor binding sites (TFBSs) …

Eukaryotes have evolved a specific strategy to package DNA. The nucleosome is a 147-
base-pair DNA segment wrapped around histone core proteins that plays important roles …

Nucleosome organization is important for the understanding of promoter accessibility and
transcription regulation. In the past decade, in vivo nucleosome mapping suggested a …

DNA accessibility to regulatory proteins is substantially influenced by nucleosome structure
and dynamics. The facilitates chromatin transcription (FACT) complex increases the …

Because DNA packaging in nucleosomes modulates its accessibility to transcription factors
(TFs), unraveling the causal determinants of nucleosome positioning is of great importance …

Transfer of genetic information starts with transcription factors (TFs) binding to specific sites
on DNA. But in living cells, DNA is mostly covered by nucleosomes. There are proteins …

AT-rich DNA is concentrated in the nucleosome-free regions (NFRs) associated with
transcription start sites of most genes. We tested the hypothesis that AT-rich DNA engenders …