Background Liquid biopsy, particularly cell-free RNA (cfRNA), has emerged as a promising
non-invasive diagnostic tool for various diseases, including cancer, due to its accessibility …

Hepatocellular carcinoma (HCC) is a severe neoplastic disease associated with high
morbidity and mortality rates. HCC is often detected at advanced stages leading to …

Cell-free RNA (cfRNA) in plasma reflects phenotypic alterations of both localized sites of
cancer and the systemic host response. Here we report that cfRNA sequencing enables the …

Circulating nucleic acids in blood plasma form an attractive resource to study human health
and disease. Here, we applied mRNA capture sequencing of blood plasma cell-free RNA …

Gastrointestinal (GI) cancer includes many cancer types, such as esophageal, liver, gastric,
pancreatic, and colorectal cancer. As the cornerstone of personalized medicine for GI …

The circulating cell-free nucleic acids (ccfNAs) consist of a heterogenous cocktail of both
single (ssNA) and double-stranded (dsNA) nucleic acids. These ccfNAs are secreted into the …

Abstract Background Cell‐free long RNAs in human plasma and extracellular vesicles (EVs)
have shown promise as biomarkers in liquid biopsy, despite their fragmented nature …

Regular screening for colorectal cancer (CRC) is critical for early detection and long-term
survival. Despite the current screening options available and advancements in therapies …

Background Human plasma contains RNA transcripts released by multiple cell types within
the body. Single-cell transcriptomic analysis allows the cellular origin of circulating RNA …

Liquid biopsies using cell-free RNA (cfRNA) can noninvasively measure dynamic
physiological changes throughout the body. While there is much effort in the liquid biopsy …