Targeting janus kinases and signal transducer and activator of transcription 3 to treat inflammation, fibrosis, and cancer: rationale, progress, and caution
U Bharadwaj, MM Kasembeli, P Robinson… - Pharmacological …, 2020 - ASPET
Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
Combined anti-fibrotic and anti-inflammatory properties of JAK-inhibitors on macrophages in vitro and in vivo: perspectives for scleroderma-associated interstitial lung …
A Lescoat, M Lelong, M Jeljeli, C Piquet-Pellorce… - Biochemical …, 2020 - Elsevier
Janus kinase (JAK) inhibitors (also termed Jakinibs) constitute a family of small drugs that
target various isoforms of JAKs (JAK1, JAK2, JAK3 and/or tyrosine kinase 2 (Tyk2)). They …
target various isoforms of JAKs (JAK1, JAK2, JAK3 and/or tyrosine kinase 2 (Tyk2)). They …
Role of the JAK-STAT pathway in PDGF-stimulated proliferation of human airway smooth muscle cells
AR Simon, S Takahashi, M Severgnini… - … of Physiology-Lung …, 2002 - journals.physiology.org
Airway remodeling, as manifested by an increase in airway smooth muscle mass, mucous
gland hyperplasia, and subepithelial fibrosis, contributes to the airway hyperresponsiveness …
gland hyperplasia, and subepithelial fibrosis, contributes to the airway hyperresponsiveness …
[HTML][HTML] STAT-3 contributes to pulmonary fibrosis through epithelial injury and fibroblast-myofibroblast differentiation
M Pedroza, TT Le, K Lewis… - The FASEB …, 2016 - ncbi.nlm.nih.gov
Lung fibrosis is the hallmark of the interstitial lung diseases. Alveolar epithelial cell (AEC)
injury is a key step that contributes to a profibrotic microenvironment. Fibroblasts and …
injury is a key step that contributes to a profibrotic microenvironment. Fibroblasts and …
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential
HT Tzeng, IT Chyuan, JH Lai - Biochemical Pharmacology, 2021 - Elsevier
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling
pathway is characterized by diverse immune regulatory systems involving cell proliferation …
pathway is characterized by diverse immune regulatory systems involving cell proliferation …
[HTML][HTML] The regulation of JAKs in cytokine signaling and its breakdown in disease
HM Hammarén, AT Virtanen, J Raivola, O Silvennoinen - Cytokine, 2019 - Elsevier
The JAK–STAT signal transduction pathway is responsible for mediating signals of over fifty
cytokines, growth factors and hormones. Signaling through the JAK–STAT pathway is …
cytokines, growth factors and hormones. Signaling through the JAK–STAT pathway is …
[HTML][HTML] JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells
Abstract Epithelial-mesenchymal transition (EMT), a key step in the early stages of cancer
metastasis, is orchestrated by several signaling pathways, including IL-6/JAK/STAT3 and …
metastasis, is orchestrated by several signaling pathways, including IL-6/JAK/STAT3 and …
The specific roles of JAK/STAT signaling pathway in sepsis
B Cai, J Cai, Y Luo, C Chen, S Zhang - Inflammation, 2015 - Springer
The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway is a
principal signaling pathway for the signal transduction of many pivotal cytokines involved in …
principal signaling pathway for the signal transduction of many pivotal cytokines involved in …
Biological and clinical significance of the JAK-STAT pathway; lessons from knockout mice
Originally described as the signal-transducing pathway of interferons, the JAK-STAT
pathway soon turned out to participate in the signalling of numerous other immune and even …
pathway soon turned out to participate in the signalling of numerous other immune and even …
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
C Xue, Q Yao, X Gu, Q Shi, X Yuan, Q Chu… - Signal transduction and …, 2023 - nature.com
The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …
is an evolutionarily conserved mechanism of transmembrane signal transduction that …