The Janus kinase-signal transducer and activator of transcription (Jak-STAT) pathway is
essential for the signal transduction of many cytokines. Dysregulation of Jak-STAT signaling …

The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …

Abstract The importance of Jak-Stat pathway signaling in regulating cytokine-dependent
gene expression and cellular development/survival is well established. Nevertheless …

Rationale: Fibrosis leads to failure of the skin, lungs, and other organs in systemic sclerosis;
accounts for substantial morbidity and mortality; and lacks effective therapy. Myofibroblast …

In immune-mediated chronic inflammation the balance between pro-inflammatory and anti-
inflammatory cytokines is skewed so that elevated levels of circulating pro-inflammatory …

Background Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease
characterized by a progressive decline in lung function. Fibrotic diseases, such as IPF, are …

The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway
plays critical roles in orchestrating of immune system, especially cytokine receptors and they …

The expanding knowledge involving the cytokine transcription factor network has provided
new insights into the acute lung inflammatory response. There are numerous lung …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are diseases with
high mortality. Macrophages and neutrophils are responsible for inflammatory responses in …

COVID-19 is caused by SARS-CoV-2 infection and characterized by diverse clinical
symptoms. Type I interferon (IFN-I) production is impaired and severe cases lead to ARDS …