The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription
(STAT) pathway has an important role in the control of immune responses. Dysregulation of …

Cytokine signaling via a restricted number of Jak-Stat pathways positively and negatively
regulates all cell types involved in the initiation, propagation, and resolution of inflammation …

Fibroblast differentiation is a key cellular process that underlies the process of fibrosis, a
deadly complication of fibrotic diseases like scleroderma (SSc). This transition coincides …

More than two decades ago, experiments on the antiviral mechanisms of IFNs led to the
discovery of JAKs and their downstream effectors, the STAT proteins. This pathway has …

Four Janus kinases (JAKs)(JAK1, JAK2, JAK3, TYK2) and seven signal transducers and
activators of transcription (STATs)(STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B …

Background: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease
characterised by accumulation of activated (myo) fibroblasts and excessive extracellular …

Lung inflammation has many etiologies, including diseases of Th2-type immunity, such as
asthma and anti-parasitic responses. Inflammatory diseases of the lung involve complex …

In this era, it is axiomatic that cytokines have critical roles in cellular development and
differentiation, immune homeostasis, and host defense. Equally, dysregulation of cytokines …

Tissue injury and inflammatory response trigger the development of fibrosis in various
diseases. It has been recognized that both innate and adaptive immune cells are important …

From the‡ Departments of Microbiology and Medicine, Columbia University, New York, New
York 10032, § Departments of Pathology and Microbiology, New York University School of …