Osteoarthritis (OA) is a multifactorial chronic disease primarily characterized by the
degeneration of articular cartilage. Currently, there is a lack of effective treatments for OA …

The JAK–STAT signaling pathway has been implicated in mediating biologic responses
induced by many cytokines. However, cytokines that promote distinct cellular responses …

The Janus kinases (JAKs) are a family of intracellular tyrosine kinases that play an essential
role in the signaling of numerous cytokines that have been implicated in the pathogenesis of …

The immune response is regulated by the concerted action of pro-and anti-inflammatory
cytokines. The deregulation of this process causes immunological disorders like allergic and …

Signaling pathways initiated at the external cell surface or within the cytoplasm regulate
transactivation of transcription factors and gene expression that are causally related to a …

The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton
(STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for …

Skeletal muscle satellite cell-derived myoblasts are mainly responsible for postnatal muscle
growth and injury-induced regeneration. However, the cellular signaling pathways that …

The lung is an organ for host defense to clear up pathogens through innate and adaptive
immunity. This process involves up-regulation of proinflammatory cytokines and chemokines …

Pulmonary fibrosis is characterized by lung fibroblast proliferation and collagen secretion. In
lipopolysaccharide (LPS)-induced acute lung injury (ALI), aberrant proliferation of lung …

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of unknown cause with a
median survival of only 3 years. Other investigators and we have shown that fibroblasts …