Purpose The purpose of this study is to evaluate the ethnicity-specific population models in
the SimCYP Simulator® for prediction of omeprazole clearance with attention to differences …

Objective The aim of this study was to evaluate the absolute bioavailability and the
metabolism of omeprazole following single intravenous and oral administrations to healthy …

What is known and objective Esomeprazole, the S‐isomer of omeprazole, is a proton pump
inhibitor which has been approved by over 125 countries, also known as NEXIUM® …

To determine if dose dependency occurs with 2 weight‐based single doses of omeprazole
in a phenotyping study as well as to quantitate 3‐month intraindividual variability of …

Objectives To explore the effect of cytochrome P450 2C19 (CYP2C19) polymorphisms on
the relationship between the pharmacokinetics and pharmacodynamics of omeprazole …

The objectives of this multiple-dose study were to compare the performance of a new
formulation of omeprazole (40 mg) with that of an established formulation and to assess the …

Background and objective Considerable ethnic differences have been reported in the
incidence of the poor metaboliser (PM) genotype of cytochrome P450 (CYP) 2C19. The …

Background: To investigate whether the pharmacodynamics and pharmacokinetics of
omeprazole (OPZ) are dependent of the CYP2C19 genotype status in Chinese people …

Polymorphisms of cytochrome P450 (CYP) enzymes can affect enzymatic activity, drug
metabolism and drug interactions. Although the potential for drug interactions is especially …

The aim of this study was to evaluate the relationship between polymorphisms in CYP2C19
and the single‐dose pharmacokinetics (PKs) of omeprazole in healthy Chinese volunteers …