Brexpiprazole is an oral antipsychotic agent indicated for use in patients with schizophrenia,
or as adjunctive treatment for major depressive disorder. As cytochrome P450 (CYP) 2D6 …

Objective Omeprazole is metabolized by the two cytochrome P450 isoforms, CYP3A
(sulfoxidation) and CYP2C19 (hydroxydation). The aim of this study was to determine …

Background: Omeprazole is metabolized predominantly by CYP2C19, a polymorphically
expressed enzymes that show marked interindividual and interethnic variation. These …

Objective The purpose of this study is to evaluate whether a simple formula using limited
blood samples can predict the area under the plasma rabeprazole concentration-time curve …

Purpose Omeprazole has (R)-and (S)-enantiomers, which exhibit different pharmacokinetics
(PK) among patients with cytochrome P450 (CYP) 2C19 genotype groups. The aim of this …

Background and purpose A triple therapy with omeprazole, amoxicillin (INN, amoxicilline),
and clarithromycin is widely used for the eradication of Helicobacter pylori. Omeprazole and …

In order to comply with the requirements for a drug listed in China, the study was developed
to compare the pharmacokinetics and relative bioavailability of two different enteric …

Studies investigating the relationship between CYP2C19 genotype and the stereoselective
metabolism of omeprazole have not been reported. In the present study, we developed a …

The pharmacokinetic-pharmacodynamic (PK-PD) relationship of the proton pump inhibitor
rabeprazole in healthy Chinese volunteers was characterized via a population approach …

Objective The hydroxylation of omeprazole, measured as the ratio of omeprazole/5-
hydroxyomeprazole in a plasma sample taken 3 h after an oral dose, is an established …