Proton pump inhibitors (PPIs) are the most potent acid suppressants available. PPIs
undergo hepatic metabolism via the CYP2C system for the isoforms CYP2C19 and CYP3A4 …

It is well known that the CYP2C19 genetic polymorphism influences the pharmacokinetics
and pharmacodynamics of proton pump inhibitors (PPIs), but no report has addressed the …

Background Our objective was to study omeprazole as a single‐dose oral probe in the
determination of CYP2C19 phenotype in black subjects and to determine the correlation …

Understanding the potential for cytochrome P450 (P450)-mediated drug-drug interactions is
a critical part of the drug discovery process. Factors such as nonspecific binding, atypical …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Asians have a higher percentage of
CYP2C19 poor metabolizers (PMs) and a high percentage of Helicobacter pylori infection …

The perimenopause and menopause are associated with manifestation of hyperacidity,
along with hot flashes (Pachman et al., 2012; Machowska et al., 2004), depression and …

Clopidogrel is an antiplatelet agent widely used in cardiovascular diseases and an inactive
prodrug that needs to be converted to an active metabolite in two sequential metabolic …

Background Esomeprazole and pantoprazole are metabolized in the liver and the
polymorphic CYP2C19 enzyme is involved in that process. This genetic polymorphism …

Omeprazole is a class referred to as proton pump inhibitor; it acts to regulate acid production
in the stomach and is used to treat various acid-related gastrointestinal disorders. In the …

The objective of this study was to determine the reliability of omeprazole as a marker for
CYP2C19 activity in Chinese subjects. In 27 healthy male Chinese subjects, the CYP2C19 …