Relatively little is known about neurobiological changes attributable to early-life stressors
(eg, orphanage rearing), even though they have been associated with a heightened risk for …

Background Early life stress (ELS) can compromise development, with higher amounts of
adversity linked to behavioral problems. To understand this linkage, a growing body of …

The early postnatal period is a highly sensitive time period for the developing brain, both in
humans and rodents. During this time window, exposure to adverse experiences can …

Early-life stress (ELS) is associated with increased vulnerability to mental disorders. The
basolateral amygdala (BLA) plays a critical role in fear conditioning and is extremely …

Species-expected caregiving early in life is critical for the normative development and
regulation of emotional behavior, the ability to effectively evaluate affective stimuli in the …

Highlights•Early-life stress is linked with vulnerability to cognitive and emotional
disorders.•Naturalistic animal models of early-life stress are critical to identify …

The characterization of adolescence as a time of “storm and stress” remains an open
debate. Intense and frequent negative affect during this period has been hypothesized to …

Early life adversity is a known risk factor for mood and anxiety disorders in adult humans
(Heim et al., 2010; Huh et al., 2014; Rehan et al., 2017). Given the prevalence of both …

Adolescence is the transition from childhood to adulthood, with onset marked by puberty and
the offset by relative independence from parents. Across species, it is a time of incredible …

Background The experience of early life stress is a consistently identified risk factor for the
development of mood and anxiety disorders. Preclinical research employing animal models …