Heterogeneous NLRP3 inflammasome signature in circulating myeloid cells as a biomarker of COVID-19 severity
Dysregulated immune response is the key factor leading to unfavorable coronavirus disease
2019 (COVID-19) outcome. Depending on the pathogen-associated molecular pattern, the …
2019 (COVID-19) outcome. Depending on the pathogen-associated molecular pattern, the …
A vicious cycle: in severe and critically Ill COVID-19 patients
The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus, is one of the fastest-evolving viral diseases …
syndrome coronavirus 2 (SARS-CoV-2) virus, is one of the fastest-evolving viral diseases …
Investigating the Nexus of NLRP3 Inflammasomes and COVID-19 Pathogenesis: Unraveling Molecular Triggers and Therapeutic Strategies
Q He, D Hu, F Zheng, W Chen, K Hu, J Liu, C Yao, H Li… - Viruses, 2024 - mdpi.com
The coronavirus disease 2019 (COVID-19) global pandemic, caused by severe acute
respiratory syndrome coronavirus type 2 (SARS-CoV-2), has been marked by severe cases …
respiratory syndrome coronavirus type 2 (SARS-CoV-2), has been marked by severe cases …
Inflammasome activation in COVID-19 patients
Severe cases of COVID-19 are characterized by a strong inflammatory process that may
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …
[HTML][HTML] Common NLRP3 inflammasome inhibitors and Covid-19: divide and conquer
Severe SARS-CoV-2 infection causes systemic inflammation, cytokine storm, and
hypercytokinemia due to activation of the release of pro-inflammatory cytokines that have …
hypercytokinemia due to activation of the release of pro-inflammatory cytokines that have …
Novel coronavirus-induced NLRP3 inflammasome activation: a potential drug target in the treatment of COVID-19
A Shah - Frontiers in immunology, 2020 - frontiersin.org
Novel coronaviruses (nCoVs) encode ion-channel proteins called viroporins such as protein
E, open reading frame 3a (ORF3a) and ORF8a. These viroporins, via mechanisms such as …
E, open reading frame 3a (ORF3a) and ORF8a. These viroporins, via mechanisms such as …
[HTML][HTML] Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients
TS Rodrigues, KSG de Sá, AY Ishimoto… - The Journal of …, 2021 - ncbi.nlm.nih.gov
Severe cases of COVID-19 are characterized by a strong inflammatory process that may
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …
The inflammasome in times of COVID-19
Coronaviruses (CoVs) are members of the genus Betacoronavirus and the Coronaviridiae
family responsible for infections such as severe acute respiratory syndrome (SARS), Middle …
family responsible for infections such as severe acute respiratory syndrome (SARS), Middle …
SARS-CoV-2 S protein activates NLRP3 inflammasome and deregulates coagulation factors in endothelial and immune cells
A Villacampa, E Alfaro, C Morales… - Cell Communication and …, 2024 - Springer
Background Hyperinflammation, hypercoagulation and endothelial injury are major findings
in acute and post-COVID-19. The SARS-CoV-2 S protein has been detected as an isolated …
in acute and post-COVID-19. The SARS-CoV-2 S protein has been detected as an isolated …
Coagulation disorders in COVID-19: role of toll-like receptors
I Biswas, GA Khan - Journal of Inflammation Research, 2020 - Taylor & Francis
Abstract Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the world.
The range of the disease is broad but among hospitalized patients with COVID-19 are …
The range of the disease is broad but among hospitalized patients with COVID-19 are …