Over the last 10 years, proofs of the clinical interest of therapeutic drug monitoring (TDM) of
certain anticancer drugs have been established. Numerous studies have shown that TDM is …

Therapeutic drug monitoring is not routinely used for chemotherapy agents. There are
Several reasons, but one major drawback is the lack of established therapeutic …

Most anticancer drugs are characterised by a steep dose–response relationship and narrow
therapeutic window. Inter-individual pharmacokinetic (PK) variability is often substantial. The …

Therapeutic drug monitoring (TDM) is increasingly used in clinical practice for the
optimisation of drug treatment. Although pharmacokinetic variability is an established factor …

For a select number of drugs, proper management of patients includes monitoring serum or
plasma concentrations of the drugs and adjusting the doses accordingly–this practice is …

Therapeutic drug monitoring is now widely used in many areas of medicine. With its
proliferation has come an understanding of the clinical situations in which it is likely to be of …

In an era when molecular and targeted anticancer therapeutics is a major focus and when
understanding drug dynamics in tumor is critical, it seems advantageous to be able to relate …

Objective Several methods have been developed for the prediction of carboplatin exposure
to facilitate pharmacokinetic guided dosing. The aim of this study was to develop and …

Introduction: Therapeutic drug monitoring in oncology is used to prevent major toxicities of
selected anticancer agents due to overexposure by individualizing the dose based on a …

Cytotoxic drugs are highly efficacious and also have low therapeutic index. A great degree
of caution needs to be exercised in their usage. To optimize the efficacy these drugs need to …