The acutely injured mammalian kidney mounts a cellular and molecular response to repair
itself. However, in patchy regions such intrinsic processes are impaired and dysregulated …

Monocyte-derived macrophages can determine the outcome of the immune response and
whether this response contributes to tissue repair or mediates tissue destruction. In addition …

The ischemically injured kidney undergoes tubular cell necrosis and apoptosis,
accompanied by an interstitial inflammatory cell infiltrate. In this study, we show that iNos …

Background: Glomerular and interstitial macrophage infiltration is a feature for both the acute
and chronic kidney diseases. Macrophages have been shown to play a diverse role in …

Acute kidney injury (AKI) is a growing global health concern, yet no treatment is currently
available to prevent it or to promote kidney repair after injury. Animal models demonstrate …

Macrophages are heterogenous cells of the innate immune system that can fluidly modulate
their phenotype to respond to their local microenvironment. They are found throughout the …

Macrophages have heterogeneous phenotypes as they exercise their twofold role in the
development and recovery of renal diseases. Some subpopulations of macrophages (M1) …

Macrophages are found in normal kidney and in increased numbers in diseased kidney,
where they act as key players in renal injury, inflammation, and fibrosis. Macrophages are …

Terminally differentiated cells can be reprogrammed to pluripotency or directly to another
differentiated cell type in vitro, a capacity termed cellular plasticity. Plasticity is not limited to …

Acute ischemic kidney injury is a common complication in hospitalized patients. No
treatment is yet available for augmenting kidney repair or preventing progressive kidney …