Surface energy analysis as a tool to probe the surface energy characteristics of micronized materials—A comparison with inverse gas chromatography

JF Gamble, M Leane, D Olusanmi, M Tobyn… - International journal of …, 2012 - Elsevier
This study investigates the impact of micronization on the measured surface energy
characteristics of an active pharmaceutical ingredient (API), Ibipinabant, by inverse gas …

Investigating the applicability of inverse gas chromatography to binary powdered systems: An application of surface heterogeneity profiles to understanding …

JF Gamble, RN Davé, S Kiang, MM Leane… - International journal of …, 2013 - Elsevier
The aim of this study was to investigate the applicability of surface energy characterization
tools such as inverse gas chromatography for the analysis of binary systems. Drug …

Characterising surface energy of pharmaceutical powders by inverse gas chromatography at finite dilution

SC Das, PJ Stewart - Journal of Pharmacy and Pharmacology, 2012 - academic.oup.com
Objectives The objectives of this project were the use of surface energy distributions in:
distinguishing the effects of magnesium stearate on the surface energy of lactose processed …

Determination of surface properties and flow characteristics of salbutamol sulphate, before and after micronisation

JC Feeley, P York, BS Sumby, H Dicks - International journal of …, 1998 - Elsevier
Inverse gas chromatography (IGC) was employed to characterise the surface
thermodynamic properties of two nominally equivalent batches of salbutamol sulphate and …

A new method to determine dispersive surface energy site distributions by inverse gas chromatography

RR Smith, DR Williams, DJ Burnett, JYY Heng - Langmuir, 2014 - ACS Publications
A computational model to predict the relative energy site contributions of a heterogeneous
material from data collected by finite dilution–inverse gas chromatography (FD-IGC) is …

Computing the surface energy distributions of heterogeneous crystalline powders

AE Jefferson, DR Williams… - Journal of adhesion …, 2011 - Taylor & Francis
Inverse Gas Chromatography (IGC) provides a powerful tool for assessing the surface
energy of powders by using different chemicals as probes. Finite Dilution Inverse Gas …

Inverse gas chromatography a tool to follow physicochemical modifications of pharmaceutical solids: Crystal habit and particles size surface effects

MG Cares-Pacheco, R Calvet, G Vaca-Medina… - International Journal of …, 2015 - Elsevier
Powders are complex systems and so pharmaceutical solids are not the exception.
Nowadays, pharmaceutical ingredients must comply with well-defined draconian …

The changes in surface energetics with relative humidity of carbamazepine and paracetamol as measured by inverse gas chromatography

MR Sunkersett, IM Grimsey, SW Doughty… - European journal of …, 2001 - Elsevier
The surface energetic parameters of carbamazepine and paracetamol have been studied
using inverse gas chromatography modified to produce dry and ambient conditions within …

Inverse gas chromatography: investigating whether the technique preferentially probes high energy sites for mixtures of crystalline and amorphous lactose

HE Newell, G Buckton - Pharmaceutical research, 2004 - Springer
Purpose. Inverse gas chromatography (IGC) is rapidly gaining popularity as a method for
assessing powder surface energy. It is vital to understand what IGC measures if results are …

A review of inverse gas chromatography and its development as a tool to characterize anisotropic surface properties of pharmaceutical solids

R Ho, JYY Heng - KONA Powder and Particle Journal, 2013 - jstage.jst.go.jp
Surface properties can profoundly impact the bulk and interfacial behavior of pharmaceutical
solids, and also their manufacturability, processability in drug product processes, dissolution …