Activated platelets and platelet-derived extracellular vesicles mediate COVID-19-associated immunothrombosis

M Ebeyer-Masotta, T Eichhorn, R Weiss… - Frontiers in Cell and …, 2022 - frontiersin.org
Activated platelets and platelet-derived extracellular vesicles (EVs) have emerged as central
players in thromboembolic complications associated with severe coronavirus disease 2019 …

Investigation of homocysteine, D-dimer and platelet count levels as potential predictors of thrombosis risk in COVID-19 patients

Z Eslamifar, M Behzadifard, E Zare - Molecular and Cellular Biochemistry, 2024 - Springer
Thrombosis plays an important role in induction of Coronavirus disease 19 (COVID-19)
complications including heart attack and stroke. Reliable biomarkers are needed to predict …

Modulation of hemostasis in COVID-19; blood platelets may be important pieces in the COVID-19 puzzle

M Ulanowska, B Olas - Pathogens, 2021 - mdpi.com
Although the precise pathogenesis of coronavirus disease 2019 (COVID-19) currently
remains unknown, its complex nature is gradually being revealed. COVID-19 is a disease …

Platelet and endothelial activation as potential mechanisms behind the thrombotic complications of COVID-19 patients

P Canzano, M Brambilla, B Porro, N Cosentino… - Basic to Translational …, 2021 - jacc.org
The authors hypothesized that the cytokine storm described in COVID-19 patients may lead
to consistent cell-based tissue factor (TF)-mediated activation of coagulation, procoagulant …

Platelet extracellular vesicles in COVID-19: Potential markers and makers

F Puhm, L Flamand, E Boilard - Journal of Leukocyte Biology, 2022 - academic.oup.com
Platelets and platelet extracellular vesicles (pEV) are at the crossroads of coagulation and
immunity. Extracellular vesicles are messengers that not only transmit signals between cells …

Platelets promote thromboinflammation in SARS-CoV-2 pneumonia

F Taus, G Salvagno, S Canè, C Fava… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Pulmonary thrombosis is observed in severe acute respiratory syndrome
coronavirus 2 pneumonia. Aim was to investigate whether subpopulations of platelets were …

Extracellular vesicles in plasma and cerebrospinal fluid in patients with COVID‐19 and neurological symptoms

A Taxiarchis, BM Bellander, J Antovic… - International Journal …, 2024 - Wiley Online Library
Introduction Increased levels of extracellular vesicles (EVs) are associated with haemostatic
disturbances in various clinical settings. However, their role in COVID‐19 patients is still not …

Platelets and antiplatelet medication in COVID-19-related thrombotic complications

WC Schrottmaier, A Pirabe, D Pereyra… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) induces a hypercoagulatory state that frequently
leads to thromboembolic complications. Whereas anticoagulation is associated with …

Prothrombotic phenotype in COVID-19: focus on platelets

C Barale, E Melchionda, A Morotti, I Russo - International Journal of …, 2021 - mdpi.com
COVID-19 infection is associated with a broad spectrum of presentations, but alveolar
capillary microthrombi have been described as a common finding in COVID-19 patients …

Circulating microparticles in the pathogenesis and early anticoagulation of thrombosis in COVID-19 with kidney injury

C Wang, C Yu, VA Novakovic, R Xie… - Frontiers in Cell and …, 2022 - frontiersin.org
As more is learned about the pathophysiological mechanisms of COVID-19, systemic
thrombosis has been recognized as being associated with more severe clinical …