A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment
There is mounting evidence that seemingly diverse psychiatric disorders share genetic
etiology, but the biological substrates mediating this overlap are not well characterized. Here …
etiology, but the biological substrates mediating this overlap are not well characterized. Here …
[HTML][HTML] Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders
Background Genetic influences on gene expression in the human fetal brain plausibly
impact upon a variety of postnatal brain-related traits, including susceptibility to …
impact upon a variety of postnatal brain-related traits, including susceptibility to …
Case-control genome-wide association study of attention-deficit/hyperactivity disorder
OBJECTIVE: Although twin and family studies have shown attention-deficit/hyperactivity
disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome …
disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome …
Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome‐wide association study of both common and …
Attention‐deficit hyperactivity disorder (ADHD) is a complex polygenic disorder. This study
aimed to discover common and rare DNA variants associated with ADHD in a large …
aimed to discover common and rare DNA variants associated with ADHD in a large …
A cross-disorder method to identify novel candidate genes for developmental brain disorders
AJ Gonzalez-Mantilla, A Moreno-De-Luca… - JAMA …, 2016 - jamanetwork.com
Importance Developmental brain disorders are a group of clinically and genetically
heterogeneous disorders characterized by high heritability. Specific highly penetrant genetic …
heterogeneous disorders characterized by high heritability. Specific highly penetrant genetic …
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder
with a major genetic component. Here, we present a genome-wide association study meta …
with a major genetic component. Here, we present a genome-wide association study meta …
Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits
The genetic architecture of psychiatric disorders is characterized by a large number of small-
effect variants located primarily in non-coding regions, suggesting that the underlying causal …
effect variants located primarily in non-coding regions, suggesting that the underlying causal …
Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development
Childhood psychiatric symptoms are often diffuse but can coalesce into discrete mental
illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic …
illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic …
[HTML][HTML] Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome
Discovering drugs that efficiently treat brain diseases has been challenging. Genetic
variants that modulate the expression of potential drug targets can be utilized to assess the …
variants that modulate the expression of potential drug targets can be utilized to assess the …
Novel loci associated with attention-deficit/hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment
AA Shadrin, OB Smeland, T Zayats, AJ Schork… - Journal of the American …, 2018 - Elsevier
Objective Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable
psychiatric condition. By exploiting the reported relationship between ADHD and …
psychiatric condition. By exploiting the reported relationship between ADHD and …