To develop and characterize a novel cell culture method for the generation of
undifferentiated and differentiated human mesenchymal stem cell 3D structures, we utilized …

A unique biomaterial-based system was developed to generate dynamic three-dimensional
(3D) multicellular spheroids of mesenchymal stem cells (MSCs). MSCs were cultured on …

Abstract Background Mesenchymal stem cells (MSCs) have to be expanded in vitro to reach
a sufficient cell dose for the treatment of various diseases. During the process of expansion …

We found adult human stem cells that can generate, from a single cell, cells with the
characteristics of the three germ layers. The cells are stress-tolerant and can be isolated …

Abstract Introduction Multipotent stromal cells (MSCs) are among the key candidates in
regenerative medicine. However variety of MSC sources and general heterogeneity lead to …

Purpose It has been reported that mesenchymal stem cells (MSCs) can differentiate into
neurons as an effect of adding extraneous factors, such as β-mercaptoethanol, dimethyl …

Isolation and purification of mesenchymal stem cells (MSCs) from mouse via plastic
adherent cultures is arduous because of the unwanted growth of hematopoietic cells and …

About 40 years ago Friedenstein described stromal cells in the bone marrow that were
spindle shaped and proliferate to form colonies. These cells attach to plastic and are able to …

Human mesenchymal stem cells (hMSCs) have the ability to differentiate into mesenchymal
lineages. In this study, we hypothesized that treatment of embryoid bodies (EBs) composed …

Human mesenchymal stromal cells (hMSCs) show great potential for clinical and
experimental use due to their capacity to self-renew and differentiate into multiple …