The Rho family small GTPases of the Ras superfamily play key roles in regulating diverse
signaling pathways that control a myriad of fundamental cellular processes such as …

The Rho family of small GTPases plays a key role in the dynamic regulation of the actin
cytoskeleton that underlies various important cellular functions such as shape changes …

Rho GTPases are a class of evolutionarily conserved proteins comprising 20 members,
which are predominantly known for their role in regulating the actin cytoskeleton. They are …

Rho proteins are small GTPases of the Ras superfamily that regulate a wide variety of
biological processes, ranging from gene expression to cell migration. Mechanistically, the …

Rho GTPases are well known for their roles in regulating cell migration, and also contribute
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …

Rho GTPases are a family of small G-proteins of the Ras superfamily. The ubiquitously
expressed Rho GTPases RhoA, Rac1, and Cdc42 are major regulators of the actin …

Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a
wide range of cellular processes, including cell migration, cell polarity and cell cycle …

Rho GTPases regulate cellular morphology and dynamics, and some are key drivers of
cancer progression. This superfamily offers attractive potential targets for therapeutic …

Much progress has been made toward deciphering RHO GTPase functions, and many
studies have convincingly demonstrated that altered signal transduction through RHO …

Rho GTPases comprise a family of molecular switches that control signal transduction
pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes …