Free p-cresyl sulfate shows the highest association with cardiovascular outcome in chronic kidney disease

G Glorieux, R Vanholder, W Van Biesen… - Nephrology Dialysis …, 2021 - academic.oup.com
Background Several protein-bound uraemic toxins (PBUTs) have been associated with
cardiovascular (CV) and all-cause mortality in chronic kidney disease (CKD) but the degree …

Does p-cresylglucuronide have the same impact on mortality as other protein-bound uremic toxins?

S Liabeuf, G Glorieux, A Lenglet, M Diouf, E Schepers… - PLoS …, 2013 - journals.plos.org
Background Uremic toxins are emerging as important, non-traditional cardiovascular risk
factors in chronic kidney disease (CKD). P-cresol has been defined as a prototype protein …

Protein-bound uremic toxins in hemodialysis patients relate to residual kidney function, are not influenced by convective transport, and do not relate to outcome

MK van Gelder, IR Middel, RWM Vernooij, ML Bots… - Toxins, 2020 - mdpi.com
Protein-bound uremic toxins (PBUTs) are predominantly excreted by renal tubular secretion
and hardly removed by traditional hemodialysis (HD). Accumulation of PBUTs is proposed to …

Meta-analysis of the associations of p-cresyl sulfate (PCS) and indoxyl sulfate (IS) with cardiovascular events and all-cause mortality in patients with chronic renal …

CJ Lin, V Wu, PC Wu, CJ Wu - PloS one, 2015 - journals.plos.org
Background Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are protein-bound uremic toxins
that increase in the sera of patients with chronic kidney disease (CKD), and are not …

Gastrointestinal-related uremic toxins in peritoneal dialysis: a pilot study with a 5-year follow-up

C Lin, C Pan, C Chuang, H Liu, F Sun, T Wang… - Archives of Medical …, 2013 - Elsevier
Background and Aims P-cresyl sulfate (PCS) and indoxyl sulfate (IS) were not only novel but
essential factors associated with cardiovascular disease and mortality in patients with …

Serum protein-bound uraemic toxins and clinical outcomes in haemodialysis patients

CJ Lin, CJ Wu, CF Pan, YC Chen… - Nephrology Dialysis …, 2010 - academic.oup.com
Background. The protein-bound uraemic toxin p-cresol is associated with immunodeficiency
in haemodialysis (HD) patients. We investigated the effect of serum p-cresol, indoxyl …

The relationship of indoxyl sulfate and p-cresyl sulfate with target cardiovascular proteins in hemodialysis patients

PH Wu, YT Lin, YW Chiu, G Baldanzi, JC Huang… - Scientific Reports, 2021 - nature.com
Protein-bound uremic toxins (Indoxyl sulfate [IS] and p-cresyl sulfate [PCS]) are both
associated with cardiovascular (CV) and all-cause mortality in subjects with chronic kidney …

Uraemic toxins and cardiovascular disease across the chronic kidney disease spectrum: an observational study

M Rossi, K Campbell, D Johnson, T Stanton… - Nutrition, Metabolism …, 2014 - Elsevier
Background and aims There is a growing body of evidence supporting the nephrovascular
toxicity of indoxyl sulphate (IS) and p-cresyl sulphate (PCS). Nonetheless, a comprehensive …

p‐Cresyl sulfate is a valuable predictor of clinical outcomes in pre‐ESRD patients

CJ Lin, CF Pan, CK Chuang, FJ Sun… - BioMed research …, 2014 - Wiley Online Library
Background/Aims. Previous studies have reported p‐cresyl sulfate (PCS) was related to
endothelial dysfunction and adverse clinical effect. We investigate the adverse effects of …

Differences in dialysis efficacy have limited effects on protein-bound uremic toxins plasma levels over time

DH Krieter, S Kerwagen, M Rüth, HD Lemke, C Wanner - Toxins, 2019 - mdpi.com
The protein-bound uremic toxins para-cresyl sulfate (pCS) and indoxyl sulfate (IS) are
associated with cardiovascular disease in chronic renal failure, but the effect of different …