During pathogenic influenza virus infection, robust cytokine production (cytokine storm),
excessive inflammatory infiltrates, and virus-induced tissue destruction all contribute to …

Initial and early tissue injury associated with severe influenza virus infection is the result of
both virus-mediated lysis of infected pulmonary cells coupled with an exuberant immune …

Cytokine storm defines a dysregulation of and an excessively exaggerated immune
response most often accompanying selected viral infections and several autoimmune …

Cytokine storm during viral infection is a prospective predictor of morbidity and mortality, yet
the cellular sources remain undefined. Here, using genetic and chemical tools to probe …

Influenza virus is a significant pathogen in humans and animals with the ability to cause
extensive morbidity and mortality. Exuberant immune responses induced following infection …

The cytokine storm is an intensified, dysregulated, tissue-injurious inflammatory response
driven by cytokine and immune cell components. The cytokine storm during influenza virus …

The pandemic 2009 influenza A H1N1 virus is associated with significant mortality.
Targeting S1PR1, which is known to modulate the immune response, provides protection …

Influenza A viruses (IAVs) remain a major health threat and a prime example of the
significance of innate immunity. Our understanding of innate immunity to IAV has grown …

Transcriptional profiles and host-response biomarkers are used increasingly to investigate
the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA …

Influenza virus infections have a significant impact on global human health. Individuals with
suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are …