Genomic architecture of autism from comprehensive whole-genome sequence annotation
B Trost, B Thiruvahindrapuram, AJS Chan… - Cell, 2022 - cell.com
Fully understanding autism spectrum disorder (ASD) genetics requires whole-genome
sequencing (WGS). We present the latest release of the Autism Speaks MSSNG resource …
sequencing (WGS). We present the latest release of the Autism Speaks MSSNG resource …
Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder
We are performing whole-genome sequencing of families with autism spectrum disorder
(ASD) to build a resource (MSSNG) for subcategorizing the phenotypes and underlying …
(ASD) to build a resource (MSSNG) for subcategorizing the phenotypes and underlying …
[HTML][HTML] Exome sequencing of extended families with autism reveals genes shared across neurodevelopmental and neuropsychiatric disorders
Abstract Background Autism spectrum disorders (ASDs) comprise a range of
neurodevelopmental conditions of varying severity, characterized by marked qualitative …
neurodevelopmental conditions of varying severity, characterized by marked qualitative …
[HTML][HTML] Genetic architecture of autism spectrum disorder: Lessons from large-scale genomic studies
L Choi, JY An - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a strong genetic
component. Recently developed genomic technologies, including microarray and next …
component. Recently developed genomic technologies, including microarray and next …
[HTML][HTML] Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism
Autism spectrum disorder (ASD) is a phenotypically and genetically heterogeneous
neurodevelopmental disorder. Despite this heterogeneity, previous studies have shown …
neurodevelopmental disorder. Despite this heterogeneity, previous studies have shown …
[PDF][PDF] Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing
Autism Spectrum Disorder (ASD) demonstrates high heritability and familial clustering, yet
the genetic causes remain only partially understood as a result of extensive clinical and …
the genetic causes remain only partially understood as a result of extensive clinical and …
Autism genetics
AM Persico, V Napolioni - Behavioural brain research, 2013 - Elsevier
Autism spectrum disorder (ASD) is a severe neuropsychiatric disease with strong genetic
underpinnings. However, genetic contributions to autism are extremely heterogeneous, with …
underpinnings. However, genetic contributions to autism are extremely heterogeneous, with …
The genetic landscape of autism spectrum disorders
RO Rosti, AA Sadek, KK Vaux… - … Medicine & Child …, 2014 - Wiley Online Library
Autism spectrum disorders (ASD s) are a group of heterogeneous neurodevelopmental
disorders that show impaired communication and socialization, restricted interests, and …
disorders that show impaired communication and socialization, restricted interests, and …
Genetic architecture in autism spectrum disorder
B Devlin, SW Scherer - Current opinion in genetics & development, 2012 - Elsevier
Autism spectrum disorder (ASD) is characterized by impairments in reciprocal social
interaction and communication, and by restricted and repetitive behaviors. Family studies …
interaction and communication, and by restricted and repetitive behaviors. Family studies …
[PDF][PDF] Genomic patterns of de novo mutation in simplex autism
To further our understanding of the genetic etiology of autism, we generated and analyzed
genome sequence data from 516 idiopathic autism families (2,064 individuals). This …
genome sequence data from 516 idiopathic autism families (2,064 individuals). This …