Background The image of the" epigenetic landscape", with a series of branching valleys and
ridges depicting stable cellular states and the barriers between those states, has been a …

The process of cell fate determination has been depicted intuitively as cells travelling and
resting on a rugged landscape, which has been probed by various theoretical studies …

Recent breakthroughs of cell phenotype reprogramming impose theoretical challenges on
unravelling the complexity of large circuits maintaining cell phenotypes coupled at many …

Models describing the process of stem-cell differentiation are plentiful, and may offer insights
into the underlying mechanisms and experimentally observed behaviour. Waddington's …

Waddington's epigenetic landscape is an abstract metaphor frequently used to represent the
relationship between gene activity and cell fates during development. Over the past few …

The Waddington epigenetic landscape has become an iconic representation of the cellular
differentiation process. Recent single-cell transcriptomic data provide new opportunities for …

Fate decisions in developing tissues involve cells transitioning between discrete cell states,
each defined by distinct gene expression profiles. The Waddington landscape, in which the …

Robust temporal and spatial patterns of cell types emerge in the course of normal
development in multicellular organisms. The onset of degenerative diseases may result from …

Cellular differentiation, reprogramming and transdifferentiation are determined by
underlying gene regulatory networks. Non-adiabatic regulation via slow binding/unbinding …

We developed a theoretical framework to prove the existence and quantify the Waddington
landscape as well as chreode-biological paths for development and differentiation. The cells …