The molecular basis for the degeneration of neurons and the deposition of amyloid in
plaques and in the cerebrovasculature in Alzheimer's disease (AD) is incompletely …

In Alzheimer's disease (AD), a progressive decline of cognitive functions is accompanied by
neuropathology that includes the degeneration of neurons and the deposition of amyloid in …

Alzheimer's disease (AD) is characterized by the extensive deposition of the 42‐amino‐acid
β‐amyloid or A4 protein in neuritic plaques and neurofibrillary tangles within the brain. This …

The β-amyloid precursor protein (APP) carries mutations in codons 717 or 670/671, which
cosegregate with familial forms of Alzheimer's disease (AD). As an initial step to study the …

A distinguishing feature of Alzheimer's disease (AD) is the deposition of amyloid plaques in
brain parenchyma. These plaques arise by the abnormal accumulation of beta A4, a …

In an attempt to elucidate the pathological implications of intracellular accumulation of the
amyloid precursor protein (APP) in postmitotic neurons in vivo, we transferred APP695 …

Transgenic mice overexpressing different forms of amyloid precursor protein (APP), ie wild
type or clinical mutants, displayed an essentially comparable early phenotype in terms of …

APP23 transgenic mice express mutant human amyloid precursor protein and develop
amyloid plaques predominantly in neocortex and hippocampus progressively with age …

Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer
disease (AD) by affecting the formation of the amyloid β (Aβ) peptide, the major constituent …

Alzheimer's disease (AD) is the most common form of dementia in the aged population.
Early-onset familial AD (FAD) involves mutations in a gene on chromosome 21 encoding the …