Objective: Minocycline, a tetracycline antibiotic, has shown anti-inflammatory effects in
cerebral ischemia and neurodegenerative disease; however, the molecular mechanisms …

Background Idebenone is a well-appreciated mitochondrial protectant while the
mechanisms underlying the neuroprotection in cerebral ischemia and reperfusion (I/R) …

Activation of the NOD-like receptor protein (NLRP3)-inflammasome has been postulated to
mediate inflammatory responses to brain damage during ischemic/reperfusion (I/R) injury …

Aims NLRP3 inflammasome has been reported associated with some inflammatory and
autoimmune diseases. We previously researches showed that interleukin-23 (IL-23) and …

Purpose Cerebral ischemia induces a profound neuro-inflammatory response, but the
underlying molecular mechanisms are poorly understood. Inflammasomes (NLRP1, NLRP3 …

Minocycline has beneficial effects in early brain injury (EBI) following subarachnoid
hemorrhage (SAH); however, the molecular mechanisms underlying these effects have not …

The most effective way to contain cerebral ischemic injury is reperfusion; however,
reperfusion itself may result in tissue injury, for which inflammatory damage is one of the …

Background Ischemic stroke immediately evokes a strong neuro-inflammatory response
within the vascular compartment, which contributes to primary infarct development under …

Ischemic stroke is a devastating disease with high morbidity and mortality rates, and the
proinflammatory microglia-mediated inflammatory response directly affects stroke outcome …

Ischemic stroke is a devastating disease with long-term disability. However, the
pathogenesis is unclear and treatments are limited. Meisoindigo, a second-generation …