A novel PI3K axis selective molecule exhibits potent tumor inhibition in colorectal carcinogenesis
A Hussain, AK Qazi, N Mupparapu… - Molecular …, 2016 - Wiley Online Library
Phosphatidylinositol‐3‐kinase (PI3K) pathway deregulation is responsible for initiation,
chemo‐resistance, and poor prognosis of colorectal cancer (CRC). Therefore, PI3K pathway …
chemo‐resistance, and poor prognosis of colorectal cancer (CRC). Therefore, PI3K pathway …
ZDQ-0620, a novel phosphatidylinositol 3-kinase inhibitor, inhibits colorectal carcinoma cell proliferation and suppresses angiogenesis by attenuating PI3K/AKT …
X Qin, M Liu, C Xu, B Xing, X Xu, Y Wu, H Ding… - Frontiers in …, 2022 - frontiersin.org
The PI3K/AKT pathway plays a central role in human cancers, aberrant activation of this
pathway is associated with tumorigenesis, cancer progression and angiogenesis. Based on …
pathway is associated with tumorigenesis, cancer progression and angiogenesis. Based on …
β-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3K
S Nie, L Chang, Y Huang, H Zhou, Q Yang… - Natural Products and …, 2024 - Springer
Abstract Phosphoinositide 3-kinase (PI3Ks) are lipid kinases widely involved in cell
proliferation, metastasis and differentiation. Constitutive activation of the PI3K/Akt/mTOR …
proliferation, metastasis and differentiation. Constitutive activation of the PI3K/Akt/mTOR …
PI3K/Akt/mTOR pathway as a therapeutic target for colorectal cancer: a review of preclinical and clinical evidence
A Narayanankutty - Current drug targets, 2019 - ingentaconnect.com
Background: Phosphoinositide 3-kinase (PI3Ks) is a member of intracellular lipid kinases
and involved in the regulation of cellular proliferation, differentiation and survival …
and involved in the regulation of cellular proliferation, differentiation and survival …
Design, synthesis and bioevaluation of PI3Kα-selective inhibitors as potential colorectal cancer drugs
XM Zheng, YS Chen, YJ Ban, YJ Wang… - European Journal of …, 2023 - Elsevier
The dysregulation of the phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin
signaling pathway has been implicated in various human cancers, and isoform-selective …
signaling pathway has been implicated in various human cancers, and isoform-selective …
Modulation of glycolysis and lipogenesis by novel PI3K selective molecule represses tumor angiogenesis and decreases colorectal cancer growth
Abstract Phosphatidylinositol 3-kinase (PI3K) pathway drives cancer progression through
direct regulation of most oncogenic properties. Here, we report that PI3K pathway signaling …
direct regulation of most oncogenic properties. Here, we report that PI3K pathway signaling …
Therapeutic targeting of the phosphatidylinositol 3-kinase signaling pathway: novel targeted therapies and advances in the treatment of colorectal cancer
M Yu, WM Grady - Therapeutic advances in gastroenterology, 2012 - journals.sagepub.com
Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the USA,
and more effective treatment of CRC is therefore needed. Advances in our understanding of …
and more effective treatment of CRC is therefore needed. Advances in our understanding of …
Targeted inhibition of the phosphoinositide 3-kinase impairs cell proliferation, survival, and invasion in colon cancer
F Yang, JY Gao, H Chen, ZH Du, XQ Zhang… - OncoTargets and …, 2017 - Taylor & Francis
Background Colon cancer is the third most common cancer in the world, and its metastasis
and drug resistance are challenging for its effective treatment. The PI3K/Akt/mTOR pathway …
and drug resistance are challenging for its effective treatment. The PI3K/Akt/mTOR pathway …
Targeting the PI3K signalling as a therapeutic strategy in colorectal cancer
MS Fernandes, JM Sanches, R Seruca - Targeted Therapy of Colorectal …, 2018 - Springer
Colorectal cancer (CRC) remains one of the leading causes of cancer mortality worldwide.
Regarded as a heterogeneous disease, a number of biomarkers have been proposed to …
Regarded as a heterogeneous disease, a number of biomarkers have been proposed to …
Therapeutic potential of targeting PI3K/AKT pathway in treatment of colorectal cancer: rational and progress
A Bahrami, M Khazaei, M Hasanzadeh… - Journal of cellular …, 2018 - Wiley Online Library
ABSTRACT PI3K/AKT/mTOR signaling pathway is one of the key dysregulated pathways in
different tumor types, including colorectal cancer (CRC). Activation of this pathway is shown …
different tumor types, including colorectal cancer (CRC). Activation of this pathway is shown …